| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4424223 | B | Activation of human Nav1.1 expressed in T-Rex-CHO cells assessed as change in decay time constant of channel currents at 1 uM by Q-patch assay relative to control | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
| 2. | ALA4424229 | B | Activation of human Nav1.1 expressed in T-Rex-CHO cells assessed as change in top peak current at 1 uM by Q-patch assay relative to control | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 3. | ALA4424230 | B | Activation of human Nav1.1 expressed in T-Rex-CHO cells assessed as change in decay time constant of channel currents at 0.3 uM at holding potential of -120 mV by automated patch-clamp electrophysiology assay relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 4. | ALA4424231 | B | Activation of human Nav1.1 expressed in T-Rex-CHO cells assessed as change in decay time constant of channel currents at 0.03 uM by Q-patch assay relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 5. | ALA4424232 | B | Activation of human Nav1.1 expressed in T-Rex-CHO cells assessed as change in decay time constant of channel currents at 0.1 uM by Q-patch assay relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 6. | ALA4424233 | A | Efflux ratio of permeability across pig LLC-PK1 cells expressing human MDR1 at 1 uM after 1 hr by LC-MS/MS analysis | Sus scrofa | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4424234 | A | Drug uptake in mouse plasma at 30 mg/kg, ip measured at 1 hr by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA4424235 | A | Drug uptake in mouse brain at 30 mg/kg, ip measured at 1 hr by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA4424236 | A | Ratio of drug level in brain to plasma in mouse at 30 mg/kg, ip measured at 1 hr by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA4424237 | A | Fraction unbound in mouse brain at 30 mg/kg, ip measured at 1 hr by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA4424238 | A | Free drug level in mouse brain at 30 mg/kg, ip measured at 1 hr by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA4424239 | B | Activation of human Nav1.2 expressed in T-Rex-CHO cells assessed as change in decay time constant of channel currents at 1 uM at holding potential of -120 mV by automated patch-clamp electrophysiology assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4424240 | B | Activation of human Nav1.3 expressed in CHO cells assessed as change in decay time constant of channel currents at 1 uM at holding potential of -120 mV by automated patch-clamp electrophysiology assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4424241 | B | Activation of human Nav1.5 expressed in T-Rex-CHO cells assessed as change in decay time constant of channel currents at 1 uM at holding potential of -120 mV by automated patch-clamp electrophysiology assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4424242 | B | Activation of human Nav1.6 expressed in T-Rex-CHO cells assessed as change in decay time constant of channel currents at 1 uM at holding potential of -120 mV by automated patch-clamp electrophysiology assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4424243 | B | Activation of human Nav1.2 expressed in T-Rex-CHO cells assessed as change in peak current at 1 uM by Q-patch assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4424244 | B | Activation of human Nav1.3 expressed in CHO cells assessed as change in peak current at 1 uM by Q-patch assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4424245 | B | Activation of human Nav1.5 expressed in T-Rex-CHO cells assessed as change in peak current at 1 uM by Q-patch assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4424246 | B | Activation of human Nav1.6 expressed in T-Rex-CHO cells assessed as change in peak current at 1 uM by Q-patch assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4424249 | B | Activation of human Nav1.1 expressed in T-Rex-CHO cells assessed as change in decay time constant of channel currents at 1 uM at holding potential of -120 mV by automated patch-clamp electrophysiology assay relative to control | Homo sapiens | 12 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!