Assay

#	Aladdin ID	Assay Type	Description	Organism	Compounds	BAO Format	Source
1.	ALA4418717	B	Substrate activity at LRAT in bovine RPE microsomes at 1 mM incubated for 1 hr at 37 degC by HPLC analysis relative to corresponding primary alcohols	Bos taurus	36	assay format	Patent Bioactivity Data
2.	ALA4418718	F	Protective effect against intense light-induced retinal degeneration in 4 weeks old Abca4(-/-)/Rdh8 (-/-) mouse assessed as effect on thickness of outer nuclear layer at 1 mg dosed via gavage under dark for 24 hrs before exposure to 10000 lux bright light for 1 hr by SDOCT and ERG analysis	Mus musculus	12	organism-based format	Patent Bioactivity Data
3.	ALA4418719	B	Inhibition of RPE65 in bovine RPE microsomes assessed as reduction in 11-cis-retinol production pre-incubated at room temperature for 5 mins before all-trans-retinol addition and further incubated for 15 mins to 2 hrs in presence of CRALBP by normal phase HPLC analysis	Bos taurus	36	assay format	Patent Bioactivity Data
4.	ALA4418720	T	Toxicity in 4 weeks old Abca4(-/-)/Rdh8 (-/-) mouse model of intense light-induced retinal degeneration at 1 mg dosed via gavage under dark for 24 hrs before exposure to 10000 lux bright light for 1 hr by SDOCT and ERG analysis	Mus musculus	12	organism-based format	Patent Bioactivity Data
5.	ALA4418721	A	Drug metabolism in 4 weeks old Abca4(-/-)/Rdh8 (-/-) mouse model of intense light-induced retinal degeneration assessed as accumulation of intense amide peaks in liver at 1 mg dosed via gavage under dark for 24 hrs before exposure to 10000 lux bright light for 1 hr by SDOCT and ERG analysis	Mus musculus	3	organism-based format	Patent Bioactivity Data
6.	ALA4418722	F	Protective effect against intense light-induced retinal degeneration in 4 weeks old Abca4(-/-)/Rdh8 (-/-) mouse assessed as 11-cis retinal levels at 1 mg dosed via gavage under dark for 24 hrs before exposure to 10000 lux bright light for 1 hr by HPLC analysis	Mus musculus	3	organism-based format	Patent Bioactivity Data