| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4414743 | B | Inhibition of human 5-LO transfected in HEK293 cells coexpressing FLAP assessed as reduction in leukotriene formation at 1 uM using arachidonic acid as substrate preincubated for 5 mins followed by calcium ionophore A23187/arachidonic acid addition and measured after 15 mins by RP-HPLC analysis | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 2. | ALA4414744 | B | Inhibition of 5-LO in human PMNL cells assessed as reduction in leukotriene formation at 1 uM preincubated for 5 mins followed by thapsigargin stimulation measured after 15 mins by RP-HPLC analysis relative to control | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 3. | ALA4414745 | B | Inhibition of 5-LO in human PMNL cells assessed as reduction in leukotriene formation preincubated for 5 mins followed by thapsigargin stimulation measured after 15 mins by RP-HPLC analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 4. | ALA4414746 | B | Potency index, ratio of Zileuton IC50 to compound IC50 for inhibition of 5-LO in human PMNL cells assessed as reduction in leukotriene formation preincubated for 5 mins followed by thapsigargin stimulation measured after 15 mins by RP-HPLC analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 5. | ALA4414747 | B | Potency index, ratio of CAPE IC50 to compound IC50 for inhibition of 5-LO in human PMNL cells assessed as reduction in leukotriene formation preincubated for 5 mins followed by thapsigargin stimulation measured after 15 mins by RP-HPLC analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA4414748 | F | Antioxidant activity assessed as DPPH radical scavenging activity incubated for 30 mins under dark condition | 6 | assay format | Scientific Literature | |||
| 7. | ALA4414749 | F | Cytotoxicity against VHL-positive human RCC10 cells assessed as reduction in cell viability incubated for 4 days by XTT assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 8. | ALA4414751 | F | Cytotoxicity against VHL-deficient human RCC4 cells assessed as reduction in cell viability incubated for 4 days by XTT assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 9. | ALA4414752 | F | Cytotoxicity against VHL-positive human RCC4/VHL cells assessed as reduction in cell viability incubated for 4 days by XTT assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 10. | ALA4414753 | F | Cytotoxicity against VHL-deficient human RCC10 cells assessed as reduction in cell viability incubated for 4 days by XTT assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 11. | ALA4414754 | F | Cytotoxicity against VHL-deficient human 786-0 cells assessed as reduction in cell viability incubated for 4 days by XTT assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 12. | ALA4414755 | F | Cytotoxicity against VHL-positive human 786-0 cells assessed as reduction in cell viability incubated for 4 days by XTT assay | Homo sapiens | 5 | cell-based format | Scientific Literature |
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