# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4480191 | Functional | Inhibition of IL-17AA production in anti-CD3 and anti-CD28 stimulated human PBMC measured after 1 hr by Sandwich ELISA | Homo sapiens | 5 | ALA4477267 | cell-based format | Scientific Literature | |
2. | ALA4480192 | Functional | Inhibition of IL-17AA production in anti-CD3 and anti-CD28 stimulated human PBMC measured after 1 hr by Sandwich ELISA relative to control | Homo sapiens | 5 | ALA4477267 | cell-based format | Scientific Literature | |
3. | ALA4480193 | Functional | Inhibition of IFN-gamma production in anti-CD3 and anti-CD28 stimulated human PBMC measured after 1 hr by Sandwich ELISA | Homo sapiens | 5 | ALA4477267 | cell-based format | Scientific Literature | |
4. | ALA4480194 | ADME | Cytotoxicity against human PBMC assessed as cell viability measured after 48 hrs by CellTiter-Glo assay | Homo sapiens | 5 | ALA4477267 | cell-based format | Scientific Literature | |
5. | ALA4480195 | Binding | Inverse agonist activity at GAL4-fused human RORc expressed in HEK293 cells assessed as activation of basal transcriptional activity by dual-glo luciferase reporter gene assay | Homo sapiens | 4 | ALA4477267 | cell-based format | Scientific Literature | |
6. | ALA4480196 | Binding | Inverse agonist activity at GAL4-fused human RORa expressed in HEK293 cells assessed as activation of basal transcriptional activity by dual-glo luciferase reporter gene assay | Homo sapiens | 4 | ALA4477267 | cell-based format | Scientific Literature | |
7. | ALA4480197 | Binding | Inverse agonist activity at GAL4-fused human RORb expressed in HEK293 cells assessed as activation of basal transcriptional activity by dual-glo luciferase reporter gene assay | Homo sapiens | 4 | ALA4477267 | cell-based format | Scientific Literature | |
8. | ALA4480198 | Physicochemical | Aqueous kinetic solubility of the compound in pH 7.4 by high-throughput assay | 2 | ALA4477267 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA4480199 | ADME | Protein binding in human plasma by equilibrium dialysis | Homo sapiens | 2 | ALA4477267 | cell-free format | Scientific Literature | |
10. | ALA4480200 | ADME | Protein binding in rat plasma by equilibrium dialysis | Rattus norvegicus | 2 | ALA4477267 | cell-free format | Scientific Literature | |
11. | ALA4480201 | ADME | Protein binding in mouse plasma by equilibrium dialysis | Mus musculus | 2 | ALA4477267 | cell-free format | Scientific Literature | |
12. | ALA4480202 | ADME | Apparent permeability from apical to basolateral side in MDCK cells | Canis lupus familiaris | 2 | ALA4477267 | cell-based format | Scientific Literature | |
13. | ALA4480203 | ADME | Apparent permeability from basolateral to apical side in MDCK cells | Canis lupus familiaris | 2 | ALA4477267 | cell-based format | Scientific Literature |