| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4385786 | A | Inhibition of CYP3A4 in human liver microsomes using [14C]-erythromycin as substrate preincubated for 2 mins in presence of NADPH followed by substrate addition and measured after 5 mins by liquid scintillation counting method | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 2. | ALA4385787 | T | Acute toxicity in po dosed KM mouse administered as single dose measured daily for 14 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 3. | ALA4385789 | A | Inhibition of PDE1B catalytic domain (10 to 487 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting method | Homo sapiens | 15 | single protein format | Scientific Literature | ||
| 4. | ALA4385790 | B | Selectivity ratio of IC50 for PDE1B catalytic domain (10 to 487 residues) (unknown origin) to IC50 for recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 | Homo sapiens | 14 | assay format | Scientific Literature | ||
| 5. | ALA4385791 | B | Selectivity ratio of IC50 for PDE2A catalytic domain (580 to 919 residues) (unknown origin) to IC50 for recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 6. | ALA4385792 | B | Inhibition of PDE2A catalytic domain (580 to 919 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 7. | ALA4385793 | A | Half life in rat liver microsomes at 1.5 uM | Rattus norvegicus | 3 | microsome format | Scientific Literature | ||
| 8. | ALA4385794 | B | Inhibition of human ERG expressed in CHO cells by patch clamp assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4385795 | A | Hepatic extraction ratio in rat liver microsomes at 1.5 uM | Rattus norvegicus | 3 | microsome format | Scientific Literature | ||
| 10. | ALA4385796 | B | Inhibition of PDE3A catalytic domain (679 to 1087 residues) (unknown origin) using 3H-cAMP as substrate after 15 mins by liquid scintillation counting method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 11. | ALA4385797 | A | Stability in rat liver microsomes assessed as stability constant at 1.5 uM | Rattus norvegicus | 3 | microsome format | Scientific Literature | ||
| 12. | ALA4385798 | A | Intrinsic clearance in rat liver microsomes at 1.5 uM | Rattus norvegicus | 3 | microsome format | Scientific Literature | ||
| 13. | ALA4385799 | A | Apparent clearance in rat liver microsomes at 1.5 uM | Rattus norvegicus | 3 | microsome format | Scientific Literature | ||
| 14. | ALA4385800 | A | Hepatic clearance in rat liver microsomes at 1.5 uM | Rattus norvegicus | 3 | microsome format | Scientific Literature | ||
| 15. | ALA4385801 | B | Inhibition of recombinant human N-terminal GST-tagged PDE1C (2 to 634 residues) expressed in baculovirus infected Sf9 cells using 3H-cGMP as substrate after 15 mins by liquid scintillation counting method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4385802 | B | Selectivity ratio of IC50 for recombinant human N-terminal GST-tagged PDE1C (2 to 634 residues) expressed in baculovirus infected Sf9 cells to IC50 for recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4385803 | B | Selectivity ratio of IC50 for PDE3A catalytic domain (679 to 1087 residues) (unknown origin) to IC50 for recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 18. | ALA4385804 | B | Inhibition of PDE8A1 catalytic domain (480 to 820 residues) (unknown origin) using [3H]-cAMP as substrate after 15 mins by liquid scintillation counting method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 19. | ALA4385805 | B | Selectivity ratio of IC50 for human PDE4D2 catalytic domain (86 to 413 residues) to IC50 for recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 20. | ALA4385806 | B | Inhibition of human PDE10A catalytic domain (449 to 770 residues) using [3H]-cAMP as substrate after 15 mins by liquid scintillation counting method | Homo sapiens | 1 | single protein format | Scientific Literature |
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