# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4478794 | B | Allosteric inhibition of HCV genotype 1b NS5A infected in human l389lucubi- neo/NS3-375.1-containing Huh7ET cells assessed as RNA replication/translation after 4 days by luciferase reporter gene assay | Hepatitis C virus subtype 1b | 20 | ALA4477222 | assay format | Scientific Literature | |
2. | ALA4478795 | B | Inhibition of human DNA polymerase-gamma by radiometric assay | Homo sapiens | 1 | ALA4477222 | assay format | Scientific Literature | |
3. | ALA4478796 | A | Cytotoxicity against human Huh7ET cells assessed as reduction in cell viability after 4 days | Homo sapiens | 20 | ALA4477222 | cell-based format | Scientific Literature | |
4. | ALA4478797 | B | Allosteric inhibition of HCV genotype 1a NS5A infected in human W11.8 cells assessed as reduction in viral RNA replication after 4 days by ELISA | Hepatitis C virus subtype 1a | 20 | ALA4477222 | cell-based format | Scientific Literature | |
5. | ALA4478798 | A | Cytotoxicity against human W11.8 cells assessed as reduction in cell viability after 4 days | Homo sapiens | 20 | ALA4477222 | cell-based format | Scientific Literature | |
6. | ALA4478799 | B | Allosteric inhibition of HCV genotype 1b NS5A infected in human l389lucubi- neo/NS3-375.1-containing Huh7ET cells assessed as RNA replication/translation after 4 days in presence of 40% human serum by luciferase reporter gene assay | Hepatitis C virus subtype 1b | 2 | ALA4477222 | assay format | Scientific Literature | |
7. | ALA4478800 | B | Inhibition of human DNA polymerase-alpha by fluorescence/radiometric assay | Homo sapiens | 1 | ALA4477222 | single protein format | Scientific Literature | |
8. | ALA4478801 | B | Inhibition of human DNA polymerase-beta by fluorescence/radiometric assay | Homo sapiens | 1 | ALA4477222 | single protein format | Scientific Literature | |
9. | ALA4478802 | B | Inhibition of HCV genotype 2a NS5A | Hepatitis C virus subtype 2a | 2 | ALA4477222 | single protein format | Scientific Literature | |
10. | ALA4478803 | B | Inhibition of HCV genotype 1a NS5B L419M mutant | Hepatitis C virus subtype 1a | 2 | ALA4477222 | single protein format | Scientific Literature | |
11. | ALA4478804 | B | Inhibition of HCV genotype 1a NS5B L419I mutant | Hepatitis C virus subtype 1a | 2 | ALA4477222 | single protein format | Scientific Literature | |
12. | ALA4478805 | B | Inhibition of HCV genotype 1a NS5B M423I mutant | Hepatitis C virus subtype 1a | 2 | ALA4477222 | single protein format | Scientific Literature | |
13. | ALA4478806 | B | Inhibition of HCV genotype 1a NS5B M423T mutant | Hepatitis C virus subtype 1a | 2 | ALA4477222 | single protein format | Scientific Literature | |
14. | ALA4478807 | B | Inhibition of HCV genotype 1a NS5B M423V mutant | Hepatitis C virus subtype 1a | 2 | ALA4477222 | single protein format | Scientific Literature | |
15. | ALA4478808 | B | Inhibition of HCV genotype 1b NS5B assessed as suppression of sub-genomic RNA levels at 0.5 times IC50 after 96 hrs in presence of human interferon alpha2a and ribavirin by luciferase reporter gene assay | Hepatitis C virus subtype 1b | 1 | ALA4477222 | assay format | Scientific Literature | |
16. | ALA4478809 | B | Inhibition of HCV genotype 1b NS5B assessed as suppression of sub-genomic RNA levels after 96 hrs in presence of telaprevir by luciferase reporter gene assay | Hepatitis C virus subtype 1b | 1 | ALA4477222 | assay format | Scientific Literature | |
17. | ALA4478810 | A | Metabolic stability in rat hepatocytes assessed as compound remaining at 10 uM after 2 hrs | Rattus norvegicus | 1 | ALA4477222 | cell-based format | Scientific Literature | |
18. | ALA4478811 | A | Metabolic stability in rat liver microsomal S9 fraction assessed as compound remaining at 1 uM after 2 hrs in presence of NADPH | Rattus norvegicus | 1 | ALA4477222 | subcellular format | Scientific Literature | |
19. | ALA4478812 | A | Metabolic stability in rat liver microsomal S9 fraction assessed as compound remaining at 1 uM after 2 hrs in presence of NADPH/UDPGA | Rattus norvegicus | 1 | ALA4477222 | subcellular format | Scientific Literature | |
20. | ALA4478813 | A | Protein binding in rat liver at 1 uM | Rattus norvegicus | 1 | ALA4477222 | tissue-based format | Scientific Literature |