| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4384228 | Functional | Antiparasitic activity against Giardia lamblia WB trophozoites after 24 to 48 hrs by CellTiter-Glo luminescent cell viability assay | Giardia intestinalis | 67 | ALA4382237 | organism-based format | Scientific Literature | |
| 2. | ALA4384229 | Functional | Antiparasitic activity against Entamoeba histolytica HM-1:IMSS trophozoites after 24 to 48 hrs by CellTiter-Glo luminescent cell viability assay | Entamoeba histolytica | 50 | ALA4382237 | organism-based format | Scientific Literature | |
| 3. | ALA4384231 | Functional | Antibacterial activity against Mycobacterium tuberculosis H37Rv after 5 days under normoxic condition by resazurin dye-based fluorescence assay | Mycobacterium tuberculosis | 66 | ALA4382237 | organism-based format | Scientific Literature | |
| 4. | ALA4384233 | Functional | Antibacterial activity against non-replicating Mycobacterium tuberculosis H37Rv after 5 days under hypoxic condition by resazurin dye-based fluorescence assay | Mycobacterium tuberculosis | 64 | ALA4382237 | organism-based format | Scientific Literature | |
| 5. | ALA4384236 | Functional | Antiparasitic activity against bloodstream form of Trypanosoma brucei brucei strain 427 after 48 hrs by resazurin dye-based assay | Trypanosoma brucei brucei | 48 | ALA4382237 | organism-based format | Scientific Literature | |
| 6. | ALA4384249 | ADME | Metabolic stability in human liver microsomes assessed as parent compound remaining at 3 uM after 2 hrs by LC-MS/MS analysis | Homo sapiens | 11 | ALA4382237 | microsome format | Scientific Literature | |
| 7. | ALA4384250 | ADME | Metabolic stability in CD-1 mouse liver microsomes assessed as parent compound remaining at 3 uM after 2 hrs by LC-MS/MS analysis | Mus musculus | 11 | ALA4382237 | microsome format | Scientific Literature | |
| 8. | ALA4384251 | ADME | Metabolic stability in human plasma assessed as parent compound remaining at 3 uM after 2 hrs by LC-MS/MS analysis | Homo sapiens | 12 | ALA4382237 | cell-free format | Scientific Literature | |
| 9. | ALA4384252 | ADME | Metabolic stability in CD-1 mouse plasma assessed as parent compound remaining at 3 uM after 2 hrs by LC-MS/MS analysis | Mus musculus | 12 | ALA4382237 | cell-free format | Scientific Literature | |
| 10. | ALA4384253 | ADME | Protein binding in human plasma at 5 uM after 30 mins by LC-MS/MS analysis based ultrafiltration method | Homo sapiens | 12 | ALA4382237 | cell-free format | Scientific Literature | |
| 11. | ALA4384254 | ADME | Apparent permeability across apical to basolateral side in human Caco2 cells at 2 uM after 2 hrs by lucifer yellow dye-based LC-MS/MS analysis | Homo sapiens | 7 | ALA4382237 | cell-based format | Scientific Literature | |
| 12. | ALA4384255 | ADME | Apparent permeability across basolateral to apical side in human Caco2 cells at 2 uM after 2 hrs by lucifer yellow dye-based LC-MS/MS analysis | Homo sapiens | 7 | ALA4382237 | cell-based format | Scientific Literature | |
| 13. | ALA4384256 | ADME | Apparent permeability across apical to basolateral side in human Caco2 cells assessed as mean drug recovery at 2 uM after 2 hrs by lucifer yellow dye-based LC-MS/MS analysis | Homo sapiens | 7 | ALA4382237 | cell-based format | Scientific Literature | |
| 14. | ALA4384257 | ADME | Apparent permeability across basolateral to apical side in human Caco2 cells assessed as mean drug recovery at 2 uM after 2 hrs by lucifer yellow dye-based LC-MS/MS analysis | Homo sapiens | 7 | ALA4382237 | cell-based format | Scientific Literature | |
| 15. | ALA4384258 | ADME | Efflux ratio of apparent permeability in human Caco2 cells at 2 uM after 2 hrs by lucifer yellow dye-based LC-MS/MS analysis | Homo sapiens | 7 | ALA4382237 | cell-based format | Scientific Literature | |
| 16. | ALA4384259 | Physicochemical | Kinetic solubility of compound in water at 200 uM after 24 hrs by LC-UV analysis | 7 | ALA4382237 | small-molecule physicochemical format | Scientific Literature | ||
| 17. | ALA4384260 | Physicochemical | Kinetic solubility of compound in pH 7.4 PBS at 200 uM after 24 hrs by LC-UV analysis | 7 | ALA4382237 | small-molecule physicochemical format | Scientific Literature | ||
| 18. | ALA4296191 | Functional | Cytotoxicity against HEK293 cells (CO-ADD:MA_007); CC50 by cell viability assay in DMEM (10% FBS) media using TC plates, by Resazurin F(560/590) | Homo sapiens | 899 | ALA4296181 | cell-based format | CO-ADD antimicrobial screening data | |
| 19. | ALA5106642 | Functional | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 assessed as bacterial growth inhibition incubated for 5 days under normoxic condition by resazurin microtiter assay | Mycobacterium tuberculosis | 19 | ALA5104178 | organism-based format | Scientific Literature | |
| 20. | ALA5106643 | Functional | Antimycobacterial activity against Mycobacterium tuberculosis H37Ra ATCC 25177 assessed as bacterial growth inhibition incubated for 6 days under normoxic condition by resazurin microtiter assay | Mycobacterium tuberculosis | 11 | ALA5104178 | organism-based format | Scientific Literature |
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