# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4332905 | Binding | Displacement of [3H]-naloxone from mouse MOR expressed in CHO cell membranes by competitive radioligand binding assay | Mus musculus | 12 | ALA4330119 | cell-based format | Scientific Literature | |
2. | ALA4332906 | Binding | Displacement of [3H]-diprenorphine from mouse KOR expressed in CHO cell membranes by competitive radioligand binding assay | Mus musculus | 12 | ALA4330119 | cell-based format | Scientific Literature | |
3. | ALA4332907 | Binding | Displacement of [3H]-diprenorphine from mouse DOR expressed in CHO cell membranes by competitive radioligand binding assay | Mus musculus | 12 | ALA4330119 | cell-based format | Scientific Literature | |
4. | ALA4332908 | Binding | Selectivity ratio of Ki for mouse DOR expressed in CHO cell membranes to Ki for mouse MOR expressed in CHO cell membranes | Mus musculus | 12 | ALA4330119 | cell-based format | Scientific Literature | |
5. | ALA4332909 | Binding | Selectivity ratio of Ki for mouse KOR expressed in CHO cell membranes to Ki for mouse MOR expressed in CHO cell membranes | Mus musculus | 12 | ALA4330119 | cell-based format | Scientific Literature | |
6. | ALA4332910 | Functional | Antagonist activity at mouse MOR expressed in CHO cell membranes assessed as inhibition of DAMGO-stimulated [35S]GTPgammaS binding after 90 mins | Mus musculus | 12 | ALA4330119 | cell-based format | Scientific Literature | |
7. | ALA4332911 | Functional | Antagonist activity at mouse MOR expressed in CHO cell membranes assessed as inhibition of DAMGO-stimulated [35S]GTPgammaS binding after 90 mins relative to DAMGO | Mus musculus | 12 | ALA4330119 | cell-based format | Scientific Literature | |
8. | ALA4332913 | Functional | In vivo antagonist activity at MOR in Swiss Webster mouse assessed reduction in morphine-induced antinociceptive effect by measuring morphine MPE at 10 mg/kg, sc preincubated for 5 mins followed by morphine addition and measured after 20 min post morphine challenge by tail immersion test relative to control | Mus musculus | 12 | ALA4330119 | organism-based format | Scientific Literature |