| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4344946 | ADME | Drug metabolism assessed as recombinant CYP1A2 (unknown origin)-mediated oxidation incubated for 24 hrs in presence of NADP+ by LC-MS analysis | Homo sapiens | 1 | ALA4342479 | single protein format | Scientific Literature | |
| 2. | ALA4344947 | Unassigned | Drug metabolism assessed as intact compound incubated for 24 hrs in presence of NADP+ and absence of recombinant CYP1A2 by LC-MS analysis | 1 | ALA4342479 | assay format | Scientific Literature | ||
| 3. | ALA4344950 | Binding | Activation of ATF6 in NRVM isolated from Sprague-Dawley rat assessed as increase in GRP78 expression at 10 uM measured after 16 hrs by SYBR green dye-based qRT-PCR analysis | Rattus norvegicus | 1 | ALA4342479 | assay format | Scientific Literature | |
| 4. | ALA4344951 | Binding | Activation of ATF6 in NRVM isolated from Sprague-Dawley rat assessed as increase in catalase expression at 10 uM measured after 16 hrs by SYBR green dye-based qRT-PCR analysis | Rattus norvegicus | 1 | ALA4342479 | assay format | Scientific Literature | |
| 5. | ALA4344952 | Functional | Cytoprotection against hydrogen peroxide-induced toxicity in NRVM isolated from Sprague-Dawley rat assessed as increase in cell viability at 10 uM pretreated for 24 hrs followed by hydrogen peroxide challenge measured after 8 hrs by MTT assay | Rattus norvegicus | 2 | ALA4342479 | assay format | Scientific Literature | |
| 6. | ALA4344953 | Binding | Activation of ATF6 in simulated-ischemia-reperfusion NRVM isolated from Sprague-Dawley rat assessed as increase in cell viability by measuring media LDH content at 10 uM followed by ischemia simulation for 8 hrs and subsequent reperfusion and compound treatment for 24 hrs by LDH assay | Rattus norvegicus | 2 | ALA4342479 | single protein format | Scientific Literature | |
| 7. | ALA4344954 | Binding | Activation of ATF6 in simulated-ischemia-reperfusion NRVM isolated from Sprague-Dawley rat assessed as increase in cell viability by measuring media LDH content at 10 uM followed by ischemia simulation for 8 hrs and subsequent reperfusion and compound treatment for 24 hrs under normoxia condition by calcein-AM green dye based fluorescence microscopy | Rattus norvegicus | 2 | ALA4342479 | single protein format | Scientific Literature |
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