# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4311885 | Functional | Antioxidant activity in rat hepatic microsomes assessed as reduction in ferrous salt/ascorbic acid-induced lipid peroxidation of membrane lipids by measuring TBARS level after 45 mins by spectrophotometric method | Rattus norvegicus | 17 | ALA4308920 | microsome format | Scientific Literature | |
2. | ALA4311887 | Binding | Inhibition of SQS in rat liver microsomes assessed as reduction in [3H]FPP conversion to squalene preincubated for 10 mins followed by [3H]FPP addition and measured after 10 mins by scintillation counting method | Rattus norvegicus | 19 | ALA4308920 | microsome format | Scientific Literature | |
3. | ALA4311889 | Binding | Potency index, ratio of 2-(biphenyl-4-yl)-4-methylmorpholin-2-ol hydrobromide IC50 to compound IC50 for inhibition of SQS in rat liver microsomes | Rattus norvegicus | 3 | ALA4308920 | microsome format | Scientific Literature | |
4. | ALA4311890 | Binding | Potency index, ratio of 4-methyl-2-(4-(naphthalen-2-yl)phenyl)morpholin-2-ol hydrobromide IC50 to compound IC50 for inhibition of SQS in rat liver microsomes | Rattus norvegicus | 3 | ALA4308920 | microsome format | Scientific Literature | |
5. | ALA4311891 | Binding | Potency index, ratio of 2-(4-(6-methoxynaphthalen-2-yl)phenyl)-4-methylmorpholin-2-ol hydrobromide IC50 to compound IC50 for inhibition of SQS in rat liver microsomes | Rattus norvegicus | 3 | ALA4308920 | microsome format | Scientific Literature | |
6. | ALA4311892 | Functional | Antihypercholesterolemic activity in C57BL/6 mouse model of Triton WR1339-induced hyperlipidemia assessed as reduction in plasma total cholesterol level at 84 umol/kg, ip measured after 24 hrs relative to control | Mus musculus | 1 | ALA4308920 | organism-based format | Scientific Literature | |
7. | ALA4311893 | Functional | Antihyperlipidemic activity in C57BL/6 mouse model of Triton WR1339-induced hyperlipidemia assessed as reduction in plasma total triglyceride level at 84 umol/kg, ip measured after 24 hrs relative to control | Mus musculus | 1 | ALA4308920 | organism-based format | Scientific Literature | |
8. | ALA4311894 | Functional | In vivo antioxidant activity in C57BL/6 mouse model of Triton WR1339-induced hyperlipidemia assessed as increase in total antioxidant capacity in plasma at 84 umol/kg, ip measured after 24 hrs relative to control | Mus musculus | 1 | ALA4308920 | organism-based format | Scientific Literature | |
9. | ALA4311895 | Functional | Anti-inflammatory activity in C57BL/6 mouse assessed as inhibition of carrageenan-induced hind paw edema at 300 umol/kg, ip treated immediately after carrageenan challenge measured after 3.5 hrs relative to control | Mus musculus | 1 | ALA4308920 | organism-based format | Scientific Literature |