| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4424072 | F | Antitrypanosomal activity against Trypanosoma brucei brucei Squib 427 after 48 hrs by alamar blue assay | Trypanosoma brucei brucei | 29 | organism-based format | Scientific Literature | ||
| 2. | ALA4424073 | F | Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB-900 after 48 hrs by alamar blue assay | Trypanosoma brucei rhodesiense | 29 | organism-based format | Scientific Literature | ||
| 3. | ALA4424074 | A | Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 3 days by resazurin dye-based assay | Homo sapiens | 30 | cell-based format | Scientific Literature | ||
| 4. | ALA4424075 | T | Selectivity index, ratio of EC50 for human MRC5 cells to EC50 for Trypanosoma brucei brucei Squib 427 | 29 | assay format | Scientific Literature | |||
| 5. | ALA4424076 | T | Selectivity index, ratio of EC50 for human MRC5 cells to EC50 for Trypanosoma brucei rhodesiense STIB-900 | 29 | assay format | Scientific Literature | |||
| 6. | ALA4424077 | F | Antitrypanosomal activity against wild type Trypanosoma brucei Lister 427 after 48 hrs by alamar blue assay | Trypanosoma brucei | 5 | organism-based format | Scientific Literature | ||
| 7. | ALA4424078 | F | Antitrypanosomal activity against Trypanosoma brucei TbAT1-KO after 48 hrs by alamar blue assay | Trypanosoma brucei | 5 | organism-based format | Scientific Literature | ||
| 8. | ALA4424079 | F | Antitrypanosomal activity against pentamidine/diminazene/melaminophenyl arsenical resistant Trypanosoma brucei B48 after 48 hrs by alamar blue assay | Trypanosoma brucei | 5 | organism-based format | Scientific Literature | ||
| 9. | ALA4424080 | F | Antitrypanosomal activity against isometamidium resistant Trypanosoma brucei ISMR1 after 48 hrs by alamar blue assay | Trypanosoma brucei | 5 | organism-based format | Scientific Literature | ||
| 10. | ALA4424081 | F | Resistance factor, ratio of EC50 for Trypanosoma brucei TbAT1-KO to EC50 for wild type Trypanosoma brucei Lister 427 | Trypanosoma brucei | 5 | organism-based format | Scientific Literature | ||
| 11. | ALA4424082 | F | Resistance factor, ratio of EC50 for pentamidine/diminazene/melaminophenyl arsenical resistant Trypanosoma brucei B48 to EC50 for wild type Trypanosoma brucei Lister 427 | Trypanosoma brucei | 5 | organism-based format | Scientific Literature | ||
| 12. | ALA4424083 | F | Resistance factor, ratio of EC50 for isometamidium resistant Trypanosoma brucei B48 to EC50 for wild type Trypanosoma brucei Lister 427 | Trypanosoma brucei | 5 | organism-based format | Scientific Literature | ||
| 13. | ALA4424084 | F | Antitrypanosomal activity against nifurtimox-sensitive Trypanosoma cruzi Tulahuen CL2 harboring beta-galactosidase infected in human MRC5 cells after 7 days by resazurin dye-based assay | Trypanosoma cruzi | 29 | organism-based format | Scientific Literature | ||
| 14. | ALA4424086 | B | Inhibition of [3H]-adenosine transport at Trypanosoma brucei Adenosine transporter P1 expressed in pentamidine/diminazene/melaminophenyl arsenical resistant Trypanosoma brucei B48 bloodstream forms after 60 secs by scintillation counting analysis | Trypanosoma brucei | 5 | assay format | Scientific Literature | ||
| 15. | ALA4424087 | B | Inhibition of [3H]-adenosine transport at Trypanosoma brucei Adenosine transporter P2 expressed in pentamidine/diminazene/melaminophenyl arsenical resistant Trypanosoma brucei B48 bloodstream forms after 60 secs by scintillation counting analysis | Trypanosoma brucei | 5 | assay format | Scientific Literature | ||
| 16. | ALA4424091 | A | Drug metabolism in mouse liver S9 fraction assessed as CYP450-mediated metabolism by measuring parent compound remaining at 5 uM measured immediately in presence of NADPH by UPLC analysis | Mus musculus | 1 | subcellular format | Scientific Literature | ||
| 17. | ALA4424092 | A | Drug metabolism in mouse liver S9 fraction assessed as CYP450-mediated metabolism by measuring parent compound remaining at 5 uM measured after 15 mins in presence of NADPH by UPLC analysis | Mus musculus | 1 | subcellular format | Scientific Literature | ||
| 18. | ALA4424093 | A | Drug metabolism in mouse liver S9 fraction assessed as CYP450-mediated metabolism by measuring parent compound remaining at 5 uM measured after 30 mins in presence of NADPH by UPLC analysis | Mus musculus | 1 | subcellular format | Scientific Literature | ||
| 19. | ALA4424094 | A | Drug metabolism in mouse liver S9 fraction assessed as CYP450-mediated metabolism by measuring parent compound remaining at 5 uM measured after 60 mins in presence of NADPH by UPLC analysis | Mus musculus | 1 | subcellular format | Scientific Literature | ||
| 20. | ALA4424095 | A | Drug metabolism in rat liver S9 fraction assessed as CYP450-mediated metabolism by measuring parent compound remaining at 5 uM measured immediately in presence of NADPH by UPLC analysis | Rattus norvegicus | 1 | subcellular format | Scientific Literature |
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