# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4325750 | B | Inhibition of EL in human HT1080 cells using A10070 as substrate preincubated for 20 min followed by DMPG vesicle doped substrate addition and measured at 20 secs interval for 10 mins by fluorescence assay | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
2. | ALA4325753 | B | Inhibition of human HL expressed in human COS7 cells using A10070 as substrate preincubated for 20 min followed by DMPG vesicle doped substrate addition and measured at 20 secs interval for 10 mins by fluorescence assay | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
3. | ALA4325754 | B | Inhibition of EL in human HT1080 cells using D31-POPC-HDL as substrate incubated for 2 hrs in presence of human serum by LC/MS analysis | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
4. | ALA4325762 | A | Cmax in C57BL/6 mouse at 50 mg/kg, ip administered as nanosuspension measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
5. | ALA4325763 | A | Plasma concentration in C57BL/6 mouse at 50 mg/kg, ip administered as nanosuspension measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
6. | ALA4325764 | A | AUC (0 to 24 hrs) in C57BL/6 mouse at 50 mg/kg, ip administered as nanosuspension measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
7. | ALA4325765 | F | Antihyperlipidemic activity in C57BL/6 mouse assessed as increase in HDL-C level at 50 mg/kg, ip qd administered as nanosuspension for 2 days measured 6 hrs post-last dose by LC-MS/MS analysis relative to control | Mus musculus | 3 | organism-based format | Scientific Literature | ||
8. | ALA4325774 | B | Inhibition of endothelial lipase in hepatic lipase knock-out mouse plasma | Mus musculus | 7 | cell-free format | Scientific Literature | ||
9. | ALA4325775 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 0.5 uM incubated for 10 mins | Homo sapiens | 6 | microsome format | Scientific Literature | ||
10. | ALA4325776 | A | Metabolic stability in mouse liver microsomes assessed as compound remaining at 0.5 uM incubated for 10 mins | Mus musculus | 5 | microsome format | Scientific Literature | ||
11. | ALA4325777 | A | Metabolic stability in rat liver microsomes assessed as compound remaining at 0.5 uM incubated for 10 mins | Rattus norvegicus | 2 | microsome format | Scientific Literature | ||
12. | ALA4325778 | B | Selectivity index, ratio of IC50 for human HL expressed in human COS7 cells to IC50 for EL in human HT1080 cells | Homo sapiens | 5 | cell-based format | Scientific Literature |