# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4374364 | Functional | Neuroprotective activity against OGD-induced neurotoxicity in Sprague-Dawley rat cortical neuron assessed as cell survival rate at 0.1 uM pretreated for 24 hrs followed by incubation in oxygen and glucose deprivation medium for 2 hrs followed by exposure to reoxygenation by re-incubating in normoxia condition for 24 hrs by MTT assay (Rvb = 58.5 to 61.2 %) | Rattus norvegicus | 20 | ALA4373660 | cell-based format | Scientific Literature | |
2. | ALA4374365 | Functional | Neuroprotective activity against OGD-induced neurotoxicity in Sprague-Dawley rat cortical neuron assessed as cell survival rate at 1 uM pretreated for 24 hrs followed by incubation in oxygen and glucose deprivation medium for 2 hrs followed by exposure to reoxygenation by re-incubating in normoxia condition for 24 hrs by MTT assay (Rvb = 58.5 to 61.2 %) | Rattus norvegicus | 20 | ALA4373660 | cell-based format | Scientific Literature | |
3. | ALA4374366 | Functional | Neuroprotective activity against OGD-induced neurotoxicity in Sprague-Dawley rat cortical neuron assessed as cell survival rate at 10 uM pretreated for 24 hrs followed by incubation in oxygen and glucose deprivation medium for 2 hrs followed by exposure to reoxygenation by re-incubating in normoxia condition for 24 hrs by MTT assay (Rvb = 58.5 to 61.2 %) | Rattus norvegicus | 20 | ALA4373660 | cell-based format | Scientific Literature | |
4. | ALA4374367 | Functional | Neuroprotective activity against H2O2-induced neurotoxicity in Sprague-Dawley rat hippocampal neuron assessed as cell survival rate at 0.1 uM incubated for 24 hrs in presence of 150 uM H2O2 by MTT assay (Rvb = 41.6 to 43.2 %) | Rattus norvegicus | 6 | ALA4373660 | cell-based format | Scientific Literature | |
5. | ALA4374368 | Functional | Neuroprotective activity against H2O2-induced neurotoxicity in Sprague-Dawley rat hippocampal neuron assessed as cell survival rate at 1 uM incubated for 24 hrs in presence of 150 uM H2O2 by MTT assay (Rvb = 41.6 to 43.2 %) | Rattus norvegicus | 6 | ALA4373660 | cell-based format | Scientific Literature | |
6. | ALA4374369 | Functional | Neuroprotective activity against H2O2-induced neurotoxicity in Sprague-Dawley rat hippocampal neuron assessed as cell survival rate at 10 uM incubated for 24 hrs in presence of 150 uM H2O2 by MTT assay (Rvb = 41.6 to 43.2 %) | Rattus norvegicus | 6 | ALA4373660 | cell-based format | Scientific Literature | |
7. | ALA4374370 | Functional | Neuroprotective activity against amyloid beta (1 to 42)-induced neurotoxicity in Sprague-Dawley rat hippocampal neuron assessed as cell survival rate at 0.1 uM incubated for 48 hrs in presence of amyloid beta (1 to 42) by CellTiter Glo-based luminescence assay (Rvb = 42.1 to 43.5 %) | Rattus norvegicus | 6 | ALA4373660 | cell-based format | Scientific Literature | |
8. | ALA4374371 | Functional | Neuroprotective activity against amyloid beta (1 to 42)-induced neurotoxicity in Sprague-Dawley rat hippocampal neuron assessed as cell survival rate at 1 uM incubated for 48 hrs in presence of amyloid beta (1 to 42) by CellTiter Glo-based luminescence assay (Rvb = 42.1 to 43.5 %) | Rattus norvegicus | 6 | ALA4373660 | cell-based format | Scientific Literature | |
9. | ALA4374372 | Functional | Neuroprotective activity against amyloid beta (1 to 42)-induced neurotoxicity in Sprague-Dawley rat hippocampal neuron assessed as cell survival rate at 10 uM incubated for 48 hrs in presence of amyloid beta (1 to 42) by CellTiter Glo-based luminescence assay (Rvb = 42.1 to 43.5 %) | Rattus norvegicus | 6 | ALA4373660 | cell-based format | Scientific Literature | |
10. | ALA4374373 | ADME | Cytotoxicity against Sprague-Dawley rat cortical neuron assessed as cell survival at 3.7 uM incubated for 48 hrs by CellTiter Glo-based luminescence assay relative to control | Rattus norvegicus | 4 | ALA4373660 | cell-based format | Scientific Literature | |
11. | ALA4374374 | ADME | Cytotoxicity against Sprague-Dawley rat cortical neuron assessed as cell survival at 33.3 uM incubated for 48 hrs by CellTiter Glo-based luminescence assay relative to control | Rattus norvegicus | 4 | ALA4373660 | cell-based format | Scientific Literature | |
12. | ALA4374375 | ADME | Cytotoxicity against Sprague-Dawley rat cortical neuron assessed as cell survival at 11.1 uM incubated for 48 hrs by CellTiter Glo-based luminescence assay relative to control | Rattus norvegicus | 4 | ALA4373660 | cell-based format | Scientific Literature | |
13. | ALA4374376 | ADME | Cytotoxicity against Sprague-Dawley rat cortical neuron assessed as cell survival at 100 uM incubated for 48 hrs by CellTiter Glo-based luminescence assay relative to control | Rattus norvegicus | 4 | ALA4373660 | cell-based format | Scientific Literature | |
14. | ALA4374377 | Functional | Neuroprotective activity against amyloid beta (1 to 42)-induced neurotoxicity in Sprague-Dawley rat hippocampal neuron assessed as increase in cell survival rate incubated for 48 hrs in presence of amyloid beta (1 to 42) by CellTiter Glo-based luminescence assay | Rattus norvegicus | 4 | ALA4373660 | cell-based format | Scientific Literature | |
15. | ALA4374378 | Functional | Neuroprotective activity against H2O2-induced neurotoxicity in Sprague-Dawley rat hippocampal neuron assessed as increase in cell survival rate incubated for 24 hrs in presence of 150 uM H2O2 by MTT assay | Rattus norvegicus | 4 | ALA4373660 | cell-based format | Scientific Literature |