# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4434099 | ADME | Induction of ROS generation in human MCF7 cells at 30 uM incubated for 72 hrs by APF probe-based flow cytometer analysis relative to control | Homo sapiens | 2 | ALA4433233 | cell-based format | Scientific Literature | |
2. | ALA4434100 | Functional | Induction of ROS generation in human KB cells at 30 uM incubated for 72 hrs by APF probe-based flow cytometer analysis relative to control | Homo sapiens | 3 | ALA4433233 | cell-based format | Scientific Literature | |
3. | ALA4434101 | ADME | Cytotoxicity against human MCF7 cells in high folate medium assessed as reduction in metabolic activity at 50 uM incubated for 24 to 72 hrs by MTS assay | Homo sapiens | 2 | ALA4433233 | cell-based format | Scientific Literature | |
4. | ALA4434102 | Functional | Cytotoxicity against human KB cells in high folate medium assessed as reduction in metabolic activity at 30 uM incubated for 24 to 72 hrs by MTS assay | Homo sapiens | 2 | ALA4433233 | cell-based format | Scientific Literature | |
5. | ALA4434103 | Functional | Cytotoxicity against human IGROV1 cells in low folate medium assessed as metabolic activity at 50 uM incubated for 72 hrs by MTS assay relative to control | Homo sapiens | 2 | ALA4433233 | cell-based format | Scientific Literature | |
6. | ALA4434104 | Functional | Cytotoxicity against human IGROV1 cells in low folate medium assessed as metabolic activity at 30 uM incubated for 72 hrs by MTS assay relative to control | Homo sapiens | 2 | ALA4433233 | cell-based format | Scientific Literature | |
7. | ALA4434105 | ADME | Cytotoxicity against human MCF7 cells in low folate medium assessed as metabolic activity at 50 uM incubated for 72 hrs by MTS assay relative to control | Homo sapiens | 2 | ALA4433233 | cell-based format | Scientific Literature | |
8. | ALA4434106 | Functional | Cytotoxicity against human KB cells in low folate medium assessed as metabolic activity at 50 uM measured after 72 hrs by MTS assay relative to control | Homo sapiens | 2 | ALA4433233 | cell-based format | Scientific Literature | |
9. | ALA4434107 | ADME | Cytotoxicity against human MCF7 cells in low folate medium assessed as metabolic activity at 30 uM incubated for 72 hrs by MTS assay relative to control | Homo sapiens | 2 | ALA4433233 | cell-based format | Scientific Literature | |
10. | ALA4434108 | Functional | Cytotoxicity against human KB cells in low folate medium assessed as metabolic activity at 30 uM measured after 72 hrs by MTS assay relative to control | Homo sapiens | 2 | ALA4433233 | cell-based format | Scientific Literature | |
11. | ALA4434111 | Binding | Displacement of folate-FITC from folate receptor in human KB cells at 25 to 1000 pmol incubated for 10 mins by FITC staining-based FACS analysis | Homo sapiens | 3 | ALA4433233 | cell-based format | Scientific Literature | |
12. | ALA4434112 | Binding | Induction of Escherichia coli XL1 Blue pUC18 DNA cleavage assessed as turnover frequency in presence of DTT and 1 equivalent of (NH4)2Fe(SO4)2.6H2O at 1 uM by agarose gel electrophoresis method | Escherichia coli | 2 | ALA4433233 | nucleic acid format | Scientific Literature | |
13. | ALA4434114 | Physicochemical | Stability in pH 8.5 tris-HCl buffer assessed as cleavage of compound in presence of Fe(ClO4)2 and GSH incubated for 3 hrs by LC-MS analysis | 1 | ALA4433233 | small-molecule physicochemical format | Scientific Literature | ||
14. | ALA4434115 | Physicochemical | Stability in pH 8.5 tris-HCl buffer assessed as cleavage of compound in presence of Fe(ClO4)2 and GSH incubated for 20 mins by LC-MS analysis | 1 | ALA4433233 | small-molecule physicochemical format | Scientific Literature | ||
15. | ALA4434120 | Physicochemical | Stability in pH 8.5 tris-HCl buffer assessed as compound cleavage in presence of Fe(ClO4)2 and GSH after 5 mins by LC-MS analysis | 1 | ALA4433233 | small-molecule physicochemical format | Scientific Literature | ||
16. | ALA4434121 | Binding | Binding affinity to iron assessed as formation of iron complex in the presence of Fe(ClO4)2 and GSH after 5 mins by LC-MS analysis | 2 | ALA4433233 | assay format | Scientific Literature | ||
17. | ALA4434122 | Functional | Cytotoxicity against human KB cells in high folate medium assessed as reduction in metabolic activity at 30 uM incubated for 24 to 72 hrs in the presence of excess folic acid by MTS assay | Homo sapiens | 2 | ALA4433233 | cell-based format | Scientific Literature | |
18. | ALA4434123 | ADME | Cytotoxicity against human MCF7 cells in high folate medium assessed as reduction in metabolic activity at 30 uM incubated for 24 to 72 hrs in the presence of excess folic acid by MTS assay | Homo sapiens | 2 | ALA4433233 | cell-based format | Scientific Literature | |
19. | ALA4434124 | Functional | Cytotoxicity against human IGROV1 cells in high folate medium assessed as reduction in metabolic activity at 30 uM incubated for 24 to 72 hrs in the presence of excess folic acid by MTS assay | Homo sapiens | 2 | ALA4433233 | cell-based format | Scientific Literature |