# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4433400 | F | Antioxidant activity Wistar rat model of scopolamine-induced amnesia assessed as reduction in MDA levels in brain homogenates at 10 mg/kg, po by TBARS assay | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
2. | ALA4433401 | B | Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine iodide as substrate pre-incubated for 10 mins followed by substrate addition and measured for 6 mins by Ellman's method | Homo sapiens | 32 | single protein format | Scientific Literature | ||
3. | ALA4433402 | B | Inhibition of human serum butyrylcholinesterase using BTCI as substrate pre-incubated for 10 mins followed by substrate addition and measured for 6 mins by Ellman's method | Homo sapiens | 32 | single protein format | Scientific Literature | ||
4. | ALA4433403 | B | Non-competitive inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and measured for 6 mins by Lineweaver-Burk plot analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
5. | ALA4433404 | B | Non-competitive inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and measured for 6 mins by Dixon plot analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
6. | ALA4433405 | B | Inhibition of human BACE1 using as 7-Methoxycoumarin-4-acetyl-[Asn670, Leu671]-Amyloid beta/A4 precursor protein 770 fragment 667-676-(2,4-dinitrophenyl) Lys-Arg-Arg amide trifluoroacetate salt as substrate incubated for 2 hrs by FRET based florescence assay | Homo sapiens | 31 | single protein format | Scientific Literature | ||
7. | ALA4433406 | B | Selectivity index, ratio of IC50 for inhibition of human serum butyrylcholinesterase to IC50 for inhibition of human erythrocyte acetylcholinesterase | Homo sapiens | 21 | assay format | Scientific Literature | ||
8. | ALA4433407 | A | Permeability of the compound at 25 ug/ml after 18 hrs by PAMPA-BBB assay | 5 | assay format | Scientific Literature | |||
9. | ALA4433408 | B | Displacement of Propidium iodide from PAS region of AChE (unknown origin) at 10 uM incubated for 6 hrs by fluorescence assay relative to control | Homo sapiens | 5 | single protein format | Scientific Literature | ||
10. | ALA4433409 | B | Displacement of Propidium iodide from PAS region of AChE (unknown origin) at 50 uM incubated for 6 hrs by fluorescence assay relative to control | Homo sapiens | 5 | single protein format | Scientific Literature | ||
11. | ALA4433410 | B | Inhibition of amyloid beta 1 to 42 (unknown origin) self aggregation up to 20 uM after 48 hrs by thioflavin T-based fluorometric assay relative to donepezil | Homo sapiens | 3 | single protein format | Scientific Literature | ||
12. | ALA4433411 | B | Inhibition of human erythrocyte AChE-induced amyloid beta 1 to 42 (unknown origin) aggregation up to 20 uM after 48 hrs by thioflavin T-based fluorometric assay relative to donepezil | Homo sapiens | 3 | single protein format | Scientific Literature | ||
13. | ALA4433412 | B | Inhibition of amyloid beta 1 to 42 (unknown origin) aggregation assessed as oligomer height at 10 uM incubated for 7 days by AFM analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
14. | ALA4433413 | B | Inhibition of amyloid beta 1 to 42 (unknown origin) aggregation assessed as roughness index at 10 uM incubated for 7 days by AFM analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
15. | ALA4433414 | A | Cytotoxicity against human SH-SY5Y cells assessed as cell viability at 10 to 80 uM after 48 hrs by MTT assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
16. | ALA4433415 | T | Acute toxicity in Wistar rat assessed as induction of abnormal reactions at 100 to 500 mg/kg, po measured up to 14 days | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
17. | ALA4433416 | F | Cognitive enhancing effect in Wistar rat model of amyloid beta (1 to 42) oligomer-induced memory impairment model assessed as escape latency time at 5 mg/kg, po for 9 days by Morris water maze test (Rvb = 49.3 to 74 secs) | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
18. | ALA4433418 | F | Reversal of scopolamine-induced spatial memory impairment in Wistar rat model of amnesia assessed as decrease in transfer latency at 2.5 to 10 mg/kg, po administered once daily for 1 week followed by scopolamine challenge 30 mins prior to test by elevated plus maze test | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
19. | ALA4433420 | F | Reversal of scopolamine-induced spatial memory impairment in Wistar rat model of amnesia assessed as decrease in time spent on open arms at 2.5 to 10 mg/kg, po administered once daily for 1 week followed by scopolamine challenge 30 mins prior to test by elevated plus maze test | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
20. | ALA4433421 | F | Reversal of scopolamine-induced spatial memory impairment in Wistar rat model of amnesia assessed as increase in spontaneous alteration at 5 mg/kg, po administered once daily for 1 week followed by scopolamine challenge 30 mins prior to test by Y-maze test relative to control | Rattus norvegicus | 3 | organism-based format | Scientific Literature |