| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4414785 | B | Inhibition of fluorescein-labeled kinase tracer binding to His-TVMV-fused TYK2 JH2 domain (575 to 869 residues) (unknown origin) measured after 90 mins by HTRF assay | Homo sapiens | 22 | ALA4414548 | single protein format | Scientific Literature | |
| 2. | ALA4414789 | B | Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assay | Homo sapiens | 25 | ALA4414548 | assay format | Scientific Literature | |
| 3. | ALA4414790 | B | Inhibition of TYK2/JAK1 in IFNalpha-stimulated human Kit225 cells by steady-glo luciferase assay | Homo sapiens | 27 | ALA4414548 | assay format | Scientific Literature | |
| 4. | ALA4414793 | B | Inhibition of TYK2 JH2 domain in human whole blood assessed as inhibition of IFNalpha-induced STAT5 phosphorylation preincubated for 1 hr followed by IFNalpha stimulation and measured after 15 mins by fluorescence assay | Homo sapiens | 20 | ALA4414548 | tissue-based format | Scientific Literature | |
| 5. | ALA4414794 | B | Inhibition of [3H]cAMP binding to recombinant human His-Tb fused PDE4D2 (86 to 413 residues) expressed in Escherichia coli using [3H]cAMP as substrate preincubated for 10 mins followed by [3H]cAMP addition and measured after 1 hr by scintillation proximity assay | Homo sapiens | 7 | ALA4414548 | assay format | Scientific Literature | |
| 6. | ALA4414795 | A | Permeability across apical to basolateral side in human Caco2 cells | Homo sapiens | 17 | ALA4414548 | cell-based format | Scientific Literature | |
| 7. | ALA4414796 | A | Efflux ratio of permeability in human Caco2 | Homo sapiens | 17 | ALA4414548 | cell-based format | Scientific Literature | |
| 8. | ALA4414797 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining after 10 mins | Homo sapiens | 9 | ALA4414548 | microsome format | Scientific Literature | |
| 9. | ALA4414798 | A | Metabolic stability in rat liver microsomes assessed as parent compound remaining after 10 mins | Rattus norvegicus | 9 | ALA4414548 | microsome format | Scientific Literature | |
| 10. | ALA4414799 | A | Metabolic stability in mouse liver microsomes assessed as parent compound remaining after 10 mins | Mus musculus | 9 | ALA4414548 | microsome format | Scientific Literature |
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