| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4396801 | B | Potency index, ratio of JO146 IC50 to compound IC50 for inhibition of recombinant chlamydia trachomatis serovar L2 434/Bu/ATCC VR-902B HtrA expressed in Escherichia coli BL21(DE3) using MeOCoum-ENLHLPLPIIF-NH-DNP as fluorescent mimotope preincubated for 20 mins followed by mimotope addition in presence of fluorophore 7-methoxycoumarin-4-acetic acid by plate reader based fluorescence assay | Chlamydia trachomatis 434/Bu | 19 | ALA4393742 | assay format | Scientific Literature | |
| 2. | ALA4396802 | B | Inhibition of human neutrophil elastase using AAPV-pNA as substrate preincubated for 15 mins followed by substrate addition and measured every 15 secs for 5 mins | Homo sapiens | 23 | ALA4393742 | single protein format | Scientific Literature | |
| 3. | ALA4396803 | B | Inhibition of human trypsin using Nalpha-benzoyl-DL-R-pNA as substrate preincubated for 15 mins followed by substrate addition and measured every 15 secs for 5 mins | Homo sapiens | 23 | ALA4393742 | protein format | Scientific Literature | |
| 4. | ALA4396804 | B | Inhibition of bovine pancreas chymotrypsin using AAPF-pNA as substrate preincubated for 15 mins followed by substrate addition and measured every 15 secs for 5 mins | Bos taurus | 23 | ALA4393742 | assay format | Scientific Literature | |
| 5. | ALA4396805 | F | Antibacterial activity against Chlamydia trachomatis D/UW-3/Cx strain infected in mouse McCoy cells assessed as inclusion forming units at 100 uM treated 16 hrs post infection measured at 44 hrs post-infection by Evan's blue staining based-confocal microscopic analysis (Rvb = 62 +/- 8.5 10'5U/mL) | Chlamydia trachomatis | 22 | ALA4393742 | organism-based format | Scientific Literature | |
| 6. | ALA4396806 | B | Inhibition of recombinant chlamydia trachomatis serovar L2 434/Bu/ATCC VR-902B HtrA expressed in Escherichia coli BL21(DE3) using MeOCoum-ENLHLPLPIIF-NH-DNP as fluorescent mimotope preincubated for 20 mins followed by mimotope addition in presence of fluorophore 7-methoxycoumarin-4-acetic acid by plate reader based fluorescence assay | Chlamydia trachomatis 434/Bu | 23 | ALA4393742 | assay format | Scientific Literature | |
| 7. | ALA4396809 | F | Antibacterial activity against Chlamydia pecorum IPA ATCC VR629 infected in mouse McCoy cells assessed as inclusion forming units at 100 uM treated 16 hrs post infection measured at 44 hrs post-infection by Evan's blue staining based-confocal microscopic analysis (Rvb = 342.55646 +/- 6.53872 10'5U/mL) | Chlamydia pecorum | 12 | ALA4393742 | organism-based format | Scientific Literature | |
| 8. | ALA4840817 | B | Inhibition of recombinant ctHtrA serine protease using MeOCoum-ENLHLPLPI1F-D as substrate pretreated for 10 min followed by substrate addition and measured after 30 minutes | Chlamydia trachomatis | 14 | ALA4840314 | single protein format | Scientific Literature | |
| 9. | ALA4840818 | B | Inhibition of human neutrophil elastase using methoxysuccinyl-Ala-Ala-Pro-Val-pNA as substrate incubated for 15 min | Homo sapiens | 16 | ALA4840314 | tissue-based format | Scientific Literature | |
| 10. | ALA4840819 | B | Ratio of JO146 IC50 to test compound IC50 for inhibition of recombinant ctHtrA serine protease using Me0Coum-ENLHLPLPI1F-D as substrate pretreated for 10 minutes followed by substrate addition and measured after 30 minutes | Chlamydia trachomatis | 15 | ALA4840314 | single protein format | Scientific Literature | |
| 11. | ALA4840820 | B | Ratio of JO146 IC50 to test compound IC50 for inhibition of human neutrophil elastase using methoxysuccinyl-Ala-Ala-Pro-Val-pNA as substrate incubated for 15 min | Homo sapiens | 16 | ALA4840314 | tissue-based format | Scientific Literature | |
| 12. | ALA4840825 | F | Antibacterial activity against Pseudomonas aeruginosa assessed as growth inhibition at 50 uM | Pseudomonas aeruginosa | 3 | ALA4840314 | organism-based format | Scientific Literature | |
| 13. | ALA4840826 | F | Antibacterial activity against Staphylococcus aureus assessed as growth inhibition at 50 uM | Staphylococcus aureus | 3 | ALA4840314 | organism-based format | Scientific Literature | |
| 14. | ALA4840827 | F | Antibacterial activity against Escherichia coli assessed as growth inhibition at 50 uM | Escherichia coli | 3 | ALA4840314 | organism-based format | Scientific Literature | |
| 15. | ALA4840831 | A | Cytotoxicity against human HEp-2 cells assessed as decrease in cell integrity at 25 uM by LDH assay | Homo sapiens | 8 | ALA4840314 | cell-based format | Scientific Literature | |
| 16. | ALA5157565 | B | Inhibition of recombinant Chlamydia trachomatis HtrA serine protease using MeOCoum-ENLHLPLPI1F-D as substrate measured after 30 mins | Chlamydia trachomatis | 15 | ALA5154695 | single protein format | Scientific Literature | |
| 17. | ALA5157566 | B | Potency index, ratio of JO146 IC50 to test compound IC50 for inhibition of recombinant Chlamydia trachomatis HtrA serine protease using MeOCoum-ENLHLPLPI1F-D as substrate measured after 30 mins | Chlamydia trachomatis | 14 | ALA5154695 | single protein format | Scientific Literature | |
| 18. | ALA5157567 | B | Inhibition of human neutrophil elastase using methoxysuccinyl-Ala-Ala-Pro-Val-pNA as substrate incubated for 10 mins | Homo sapiens | 18 | ALA5154695 | single protein format | Scientific Literature | |
| 19. | ALA5157568 | B | Potency index, ratio of JO146 IC50 to test compound IC50 for inhibition of human neutrophil elastase using methoxysuccinyl-Ala-Ala-Pro-Val-pNA as substrate incubated for 10 mins | Homo sapiens | 17 | ALA5154695 | single protein format | Scientific Literature |
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