# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4364724 | B | Inhibition of human placental microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysis | Homo sapiens | 15 | subcellular format | Scientific Literature | ||
2. | ALA4364725 | B | Selectivity index, ratio of IC50 for human placental cytosolic fraction 17beta-HSD1 to IC50 for human placental microsomal fraction 17beta-HSD2 | Homo sapiens | 15 | assay format | Scientific Literature | ||
3. | ALA4364727 | B | Inhibition of human placental cytosolic fraction 17beta-HSD1 using [3H]-E1 as substrate in presence of NAD+ by radio-HPLC analysis | Homo sapiens | 15 | assay format | Scientific Literature | ||
4. | ALA4364729 | B | Inhibition of mouse liver homogenate 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysis | Mus musculus | 3 | tissue-based format | Scientific Literature | ||
5. | ALA4364732 | A | Half life in human liver S9 fraction at 1 uM in presence of NADPH | Homo sapiens | 14 | subcellular format | Scientific Literature | ||
6. | ALA4364733 | P | Aqueous solubility of the compound in phosphate-buffered saline at pH 7.2 after 1 to 24 hrs | 11 | small-molecule physicochemical format | Scientific Literature | |||
7. | ALA4364734 | B | Selectivity index, ratio of IC50 for mouse liver homogenate 17beta-HSD2 to IC50 for human placental cytosolic fraction 17beta-HSD1 | 1 | assay format | Scientific Literature | |||
8. | ALA4364735 | A | Cytotoxicity against human HEK293 cells assessed as cell viability after 66 hrs by MTT assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
9. | ALA4364736 | B | Inhibition of human steroid sulfatase expressed in T47D cells using [3H]-E1S as substrate by radio-HPLC analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature |