| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4410947 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining at 1 uM measured at 15 mins in presence of phase 1 metabolism cofactors by LC-MS/MS analysis | Homo sapiens | 17 | ALA4406914 | microsome format | Scientific Literature | |
| 2. | ALA4410948 | A | Hepatic intrinsic clearance in human Hepatocytes assessed per at 1 uM measured upto 90 mins by LC-MS/MS analysis | Homo sapiens | 17 | ALA4406914 | cell-based format | Scientific Literature | |
| 3. | ALA4410949 | B | Inhibition of human recombinant GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system using GFP-4E-BP1 peptide as substrate incubated for 1 hr by LanthaScreen assay | Homo sapiens | 19 | ALA4406914 | assay format | Scientific Literature | |
| 4. | ALA4410950 | B | Inhibition of mTORC1 in human A431 cells assessed as S6RP phosphorylation incubated for 3 hrs by HTRF assay | Homo sapiens | 19 | ALA4406914 | cell-based format | Scientific Literature | |
| 5. | ALA4410951 | B | Inhibition of mTORC2 in human A431 cells assessed as AKT phosphorylation at S473 residue incubated for 3 hrs by HTRF assay | Homo sapiens | 19 | ALA4406914 | cell-based format | Scientific Literature | |
| 6. | ALA4410952 | B | Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate measured after 30 mins by TR-FRET assay | Homo sapiens | 19 | ALA4406914 | single protein format | Scientific Literature | |
| 7. | ALA4410953 | P | Kinetic aqueous solubility of compound in phosphate buffer at pH 7.4 at 100 uM at 20 degree C shaken for 24 hrs by HPLC analysis | 19 | ALA4406914 | small-molecule physicochemical format | Scientific Literature | ||
| 8. | ALA4410954 | P | Lipophilicity, chromatographic hydrophobicity index of compound at 0.5 mM at pH 6.5 by UPLC-UV analysis | 19 | ALA4406914 | small-molecule physicochemical format | Scientific Literature | ||
| 9. | ALA4410955 | B | Inhibition of wild-type human partial length PIK3C2B (M1 to L1634 residues) expressed in mammalian expression system at 10 uM by Kinomescan method | Homo sapiens | 1 | ALA4406914 | assay format | Scientific Literature | |
| 10. | ALA4410956 | B | Inhibition of wild-type human partial length PIK3C2G (M1 to I1446 residues) expressed in mammalian expression system at 10 uM by Kinomescan method | Homo sapiens | 1 | ALA4406914 | assay format | Scientific Literature | |
| 11. | ALA4410957 | B | Inhibition of wild-type human partial length PIK3CA (R108 to N1068 residues) expressed in mammalian expression system at 10 uM by Kinomescan method | Homo sapiens | 1 | ALA4406914 | assay format | Scientific Literature | |
| 12. | ALA4410958 | B | Inhibition of human partial length PIK3CA C420R mutant (R108 to N1068 residues) expressed in mammalian expression system at 10 uM by Kinomescan method | Homo sapiens | 1 | ALA4406914 | assay format | Scientific Literature | |
| 13. | ALA4410959 | B | Inhibition of human partial length PIK3CA E542K mutant (R108 to N1068 residues) expressed in mammalian expression system at 10 uM by Kinomescan method | Homo sapiens | 1 | ALA4406914 | assay format | Scientific Literature | |
| 14. | ALA4410960 | B | Inhibition of human partial length PIK3CA E545A mutant (R108 to N1068 residues) expressed in mammalian expression system at 10 uM by Kinomescan method | Homo sapiens | 1 | ALA4406914 | assay format | Scientific Literature | |
| 15. | ALA4410961 | B | Inhibition of human partial length PIK3CA E545K mutant (R108 to N1068 residues) expressed in mammalian expression system at 10 uM by Kinomescan method | Homo sapiens | 1 | ALA4406914 | assay format | Scientific Literature | |
| 16. | ALA4410962 | B | Inhibition of human partial length PIK3CA H1047L mutant (R108 to N1068 residues) expressed in mammalian expression system at 10 uM by Kinomescan method | Homo sapiens | 1 | ALA4406914 | assay format | Scientific Literature | |
| 17. | ALA4410963 | B | Inhibition of human partial length PIK3CA H1047Y mutant (R108 to N1068 residues) expressed in mammalian expression system at 10 uM by Kinomescan method | Homo sapiens | 1 | ALA4406914 | assay format | Scientific Literature | |
| 18. | ALA4410964 | B | Inhibition of human partial length PIK3CA I800L mutant (R108 to N1068 residues) expressed in mammalian expression system at 10 uM by Kinomescan method | Homo sapiens | 1 | ALA4406914 | assay format | Scientific Literature | |
| 19. | ALA4410965 | B | Inhibition of human partial length PIK3CA M1043I mutant (R108 to N1068 residues) expressed in mammalian expression system at 10 uM by Kinomescan method | Homo sapiens | 1 | ALA4406914 | assay format | Scientific Literature | |
| 20. | ALA4410966 | B | Inhibition of human partial length PIK3CA Q546K mutant (R108 to N1068 residues) expressed in mammalian expression system at 10 uM by Kinomescan method | Homo sapiens | 1 | ALA4406914 | assay format | Scientific Literature |
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