# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4420660 | B | Inhibition of human LATS1 kinase domain (589 to 1130 amino acids) incubated for 30 mins by HTRF assay | Homo sapiens | 244 | single protein format | Patent Bioactivity Data | ||
2. | ALA4420661 | B | Inhibition of human LATS1 kinase domain (589 to 1130 amino acids) incubated for 3 hrs in presence of FAM-KKLRRTLSVA-COOH by fluorescence detection based biochemical caliper assay | Homo sapiens | 5 | single protein format | Patent Bioactivity Data | ||
3. | ALA4420662 | B | Inhibition of human LATS2 kinase domain (553 to 1088 amino acids) incubated for 3 hrs in presence of FAM-KKLRRTLSVA-COOH by fluorescence detection based biochemical caliper assay | Homo sapiens | 244 | single protein format | Patent Bioactivity Data | ||
4. | ALA4420664 | B | Inhibition of LATS in human HaCaT cells assessed as reduction in YAP phosphorylation level incubated for 2 hrs by HTRF assay | Homo sapiens | 244 | cell-based format | Patent Bioactivity Data | ||
5. | ALA4420665 | B | Inhibition of LATS in human HaCaT cells assessed as reduction in YAP nuclear translocation incubated for 24 hrs | Homo sapiens | 244 | cell-based format | Patent Bioactivity Data | ||
6. | ALA4420667 | F | Inhibition of LATS in C57BL/6 mouse with full-thickness excisional wounds assessed as up-regulation of YAP target gene Cyr61 expression at 0.2 to 2 mg/ml administered topically by RT-PCR analysis | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
7. | ALA4420668 | F | Induction of basal skin cell proliferation in C57BL/6 mouse at 250 ug administered topically twice per day by micrography | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
8. | ALA4420669 | F | Induction of epidermal thickness in C57BL/6 mouse at 250 ug administered topically twice per day by micrography | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
9. | ALA4420670 | F | Induction of skin cell proliferation in C57BL/6 mouse assessed as increase in Ki67 positive cells at 250 ug administered topically twice per day by immuno-histology staining relative to control | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
10. | ALA4420671 | B | Inhibition of LATS in human JHH5 cells assessed as reduction in YAP phosphorylation level incubated for 2 hrs by HTRF assay | Homo sapiens | 284 | cell-based format | Patent Bioactivity Data | ||
11. | ALA4420680 | B | Inhibition of LATS in human limbal epithelial cells assessed as increase in YAP level at 10 uM incubated for 24 hrs by immunostaining based assay | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
12. | ALA4420681 | B | Inhibition of LATS in human limbal epithelial cells assessed as reduction in YAP phosphorylation level at 10 uM incubated for 1 hr by Western blot analysis | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
13. | ALA4420682 | B | Inhibition of LATS in human limbal epithelial cells assessed as induction of limbal stem cell expansion by measuring p63alpha expression at 10 uM measured after 2 weeks by immunohistochemistry | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
14. | ALA4420683 | B | Inhibition of LATS in human limbal epithelial cells assessed as induction of limbal stem cell expansion by measuring expansion factor ratio at 10 uM measured after 2 weeks by p63alpha expression detection based immunohistochemistry relative to control | Homo sapiens | 18 | cell-based format | Patent Bioactivity Data | ||
15. | ALA4420684 | B | Inhibition of LATS in human limbal epithelial cells assessed as induction of limbal stem cell expansion by measuring measuring ratio of expanded population of cells to population of seeded cells at 10 uM measured after 2 weeks by p63alpha expression detection based immunohistochemistry | Homo sapiens | 18 | cell-based format | Patent Bioactivity Data | ||
16. | ALA4420685 | B | Inhibition of LATS in human limbal epithelial cells assessed as induction of limbal stem cell expansion by measuring p63alpha expression at 10 uM measured after 2 weeks by immunohistochemistry relative to control | Homo sapiens | 18 | cell-based format | Patent Bioactivity Data | ||
17. | ALA4420686 | B | Inhibition of LATS in human limbal epithelial cells assessed as induction of limbal stem cell expansion marker expression by measuring deltaN-p63-alphabetagamma protein expression at 10 uM incubated for 8 to 10 days by immunohistochemistry | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
18. | ALA4420687 | B | Inhibition of LATS in human limbal epithelial cells assessed as induction of limbal stem cell expansion marker expression by measuring ABCG2 protein expression at 10 uM incubated for 8 to 10 days by immunohistochemistry | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
19. | ALA4420688 | B | Inhibition of LATS in human limbal epithelial cells assessed as induction of limbal stem cell expansion marker expression by measuring C/EBPdelta protein expression at 10 uM incubated for 8 to 10 days by immunohistochemistry | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
20. | ALA4420695 | B | Inhibition of LATS in human corneal endothelium cells assessed as increase in YAP level at 10 uM incubated for 24 hrs by immunohistochemistry | Homo sapiens | 2 | assay format | Patent Bioactivity Data |