| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4339112 | B | Inhibition of human N-terminal GST-tagged IDO1 expressed in Escherichia coli Rosetta(DE3) pLysS using L-tryptophan as substrate measured after 1 hr by fluorescence assay | Homo sapiens | 26 | assay format | Scientific Literature | ||
| 2. | ALA4339113 | B | Inhibition of IDO1 in interferon-gamma-induced human SKOV3 cells assessed as N-formylkynurenine formation using L-tryptophan as substrate measured after 24 hrs by fluorescence assay | Homo sapiens | 26 | assay format | Scientific Literature | ||
| 3. | ALA4339114 | A | Half life in human liver microsomes | Homo sapiens | 20 | microsome format | Scientific Literature | ||
| 4. | ALA4339115 | A | Half life in mouse liver microsomes | Mus musculus | 20 | microsome format | Scientific Literature | ||
| 5. | ALA4339116 | A | Stability assessed as recombinant UGT1A9 (unknown origin) mediated compound glucuronidation by measuring half-life at 1 uM incubated in water bath by shaking at 37 degree C measured upto 60 mins in presence of UDPGA by LC-MS/MS analysis | Homo sapiens | 23 | single protein format | Scientific Literature | ||
| 6. | ALA4339117 | A | Drug metabolism in human hepatocytes assessed as parent compound remaining by measuring glucuronide formation at 5 uM measured at 120 mins by UPLC-PDA/MS analysis | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
| 7. | ALA4339118 | B | Inhibition of TDO in human HEK cells | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 8. | ALA4339119 | A | Half life in rat liver microsomes | Rattus norvegicus | 1 | microsome format | Scientific Literature | ||
| 9. | ALA4339120 | B | Inhibition IDO1 in LPS/IFN-gamma stimulated human whole blood assessed as reduction in tryptophan/kynurenine level preincubated for 15 mins followed by LPS/IFN-gamma stimulation measured after 20 hrs by LC-MS/MS analysis | Homo sapiens | 2 | tissue-based format | Scientific Literature | ||
| 10. | ALA4339121 | A | Protein binding in human plasma | Homo sapiens | 1 | cell-free format | Scientific Literature | ||
| 11. | ALA4339122 | A | Protein binding in mouse plasma | Mus musculus | 1 | cell-free format | Scientific Literature | ||
| 12. | ALA4339123 | A | Protein binding in rat plasma | Rattus norvegicus | 1 | cell-free format | Scientific Literature | ||
| 13. | ALA4339124 | A | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 14. | ALA4339125 | A | Inhibition of CYP2D6 (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 15. | ALA4339126 | A | Inhibition of CYP2C9 (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 16. | ALA4339127 | A | Inhibition of CYP2C19 (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 17. | ALA4339128 | A | Cmax in mouse at 10 mg/kg, po by capillary micro-sampling analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 18. | ALA4339129 | A | AUC (0 to 24 hrs) in mouse at 10 mg/kg, po by capillary micro-sampling analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 19. | ALA4339130 | A | Half life in mouse at 10 mg/kg, po by capillary micro-sampling analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 20. | ALA4339132 | A | Cmax in rat at 5 mg/kg, po administered as single dose by capillary micro-sampling analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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