# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4413805 | B | Binding affinity to GST-tagged ERRgamma LBD (unknown origin) using fluorescein-conjugated coactivator PGC-1alpha incubated for 1 hr by TR-FRET assay | Homo sapiens | 36 | ALA4411321 | single protein format | Scientific Literature | |
2. | ALA4413806 | B | Inverse agonist activity at CMX-gal4-fused ERRgamma (unknown origin) transfected in human AD293 cells co-expressing CMV-beta galactosidase assessed as effect on beta-galactosidase activity at 10 uM after 24 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 36 | ALA4411321 | cell-based format | Scientific Literature | |
3. | ALA4413807 | B | Binding affinity to ERRalpha (unknown origin) using fluorescein-conjugated coactivator PGC-1alpha incubated for 1 hr by TR-FRET assay | Homo sapiens | 16 | ALA4411321 | single protein format | Scientific Literature | |
4. | ALA4413808 | B | Binding affinity to ERRbeta (unknown origin) using fluorescein-conjugated coactivator PGC-1alpha incubated for 1 hr by TR-FRET assay | Homo sapiens | 16 | ALA4411321 | single protein format | Scientific Literature | |
5. | ALA4413809 | B | Binding affinity to ERalpha (unknown origin) using fluorescein-conjugated coactivator PGC-1alpha incubated for 1 hr by TR-FRET assay | Homo sapiens | 16 | ALA4411321 | single protein format | Scientific Literature | |
6. | ALA4413810 | B | Inverse agonist activity at CMX-gal4-fused ERRgamma (unknown origin) transfected in human AD293 cells co-expressing CMV-beta galactosidase assessed as effect on beta-galactosidase activity after 24 hrs by luciferase reporter gene assay | Homo sapiens | 10 | ALA4411321 | cell-based format | Scientific Literature | |
7. | ALA4413811 | A | Inhibition of CYP1A2 in human liver microsomes assessed as reduction in phenacetin O-deethylase activity at 10 uM preincubated for 5 mins followed by NADPH addition and measured after 15 mins by LC-MS/MS analysis relative to control | Homo sapiens | 10 | ALA4411321 | microsome format | Scientific Literature | |
8. | ALA4413812 | A | Inhibition of CYP2C9 in human liver microsomes assessed as reduction in tolbutamide 4-hydroxylase activity at 10 uM preincubated for 5 mins followed by NADPH addition and measured after 15 mins by LC-MS/MS analysis relative to control | Homo sapiens | 10 | ALA4411321 | microsome format | Scientific Literature | |
9. | ALA4413813 | A | Inhibition of CYP2C19 in human liver microsomes assessed as reduction in S-mephenytoin 4-hydroxylase activity at 10 uM preincubated for 5 mins followed by NADPH addition and measured after 15 mins by LC-MS/MS analysis relative to control | Homo sapiens | 10 | ALA4411321 | microsome format | Scientific Literature | |
10. | ALA4413814 | A | Inhibition of CYP2D6 in human liver microsomes assessed as reduction in dextromethorphan O-demethylase activity at 10 uM preincubated for 5 mins followed by NADPH addition and measured after 15 mins by LC-MS/MS analysis relative to control | Homo sapiens | 10 | ALA4411321 | microsome format | Scientific Literature | |
11. | ALA4413815 | A | Inhibition of CYP3A4 in human liver microsomes assessed as reduction in midazolam 1-hydroxylase activity at 10 uM preincubated for 5 mins followed by NADPH addition and measured after 15 mins by LC-MS/MS analysis relative to control | Homo sapiens | 10 | ALA4411321 | microsome format | Scientific Literature | |
12. | ALA4413816 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 1 uM after 30 mins in presence of NADPH regeneration system by LC-MS/MS analysis | Homo sapiens | 10 | ALA4411321 | microsome format | Scientific Literature | |
13. | ALA4413817 | A | Metabolic stability in dog liver microsomes assessed as compound remaining at 1 uM after 30 mins in presence of NADPH regeneration system by LC-MS/MS analysis | Canis lupus familiaris | 10 | ALA4411321 | microsome format | Scientific Literature | |
14. | ALA4413818 | A | Metabolic stability in rat liver microsomes assessed as compound remaining at 1 uM after 30 mins in presence of NADPH regeneration system by LC-MS/MS analysis | Rattus norvegicus | 10 | ALA4411321 | microsome format | Scientific Literature | |
15. | ALA4413819 | A | Metabolic stability in mouse liver microsomes assessed as compound remaining at 1 uM after 30 mins in presence of NADPH regeneration system by LC-MS/MS analysis | Mus musculus | 10 | ALA4411321 | microsome format | Scientific Literature | |
16. | ALA4413820 | A | Effective permeability of the compound at 10 uM after 5 hrs by PAMPA | 10 | ALA4411321 | assay format | Scientific Literature | ||
17. | ALA4413821 | B | Inhibition of human ERG after 4 hrs by fluorescence polarization assay | Homo sapiens | 10 | ALA4411321 | single protein format | Scientific Literature |