# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4392552 | B | Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (1 to 637 residue) /full length human N-terminal His tagged MEP50 expressed in baculovirus infected Sf9 insect cells assessed as reduction in methyl transfer from [3H]-SAM to biotinylated histone H4 peptide H-SGRGKGGKGLGKGGAKRHRKVLRDK-Biotin measured after 2 hrs by liquid scintillation counting | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
2. | ALA4392553 | B | Inhibition of full length N-terminal FLAG-tagged PRMT5 (unknown origin)/MEP50 (unknown origin) expressed in baculovirus infected Sf21 insect cells using H4(1-21) peptide SGRGKGGKGLGKGGAKRHRKV as substrate measured after 25 minutes in the presence of [3H]SAM by liquid scintillation counting | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
3. | ALA4392556 | F | Antiproliferative activity against human A375 cells measured after 7 days by cell titer glo-based luminescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
4. | ALA4392557 | F | Antiproliferative activity against human A549 cells incubated for 7 days with compound replacement on day 4 by cell titer glo-based luminescence assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
5. | ALA5249958 | F | Anticancer activity against human A-375 cells in xenograft model assessed as tumor growth inhibition at 10 mg/kg, qd on a 4 day-on/3 day-off schedule for 26 days relative to control | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
6. | ALA5249967 | B | Inhibition of PRMT5 (unknown origin) | Homo sapiens | 4 | single protein format | Scientific Literature | ||
7. | ALA5249968 | F | Antiproliferation activity against human A-375 cells assessed as cell growth inhibition | Homo sapiens | 3 | cell-based format | Scientific Literature |