# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4381084 | F | Cytotoxicity against human PANC1 cells assessed as reduction in metabolic activity at 20 nM after 24 to 72 hrs in dark followed by photoirradiation in presence of NADH by resazurin assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
2. | ALA4381085 | A | Drug uptake in mouse NIH/3T3 cells at 5 uM and 4 degree C after 16 hrs by FACS analysis relative to 37 degree C | Mus musculus | 2 | cell-based format | Scientific Literature | ||
3. | ALA4381086 | B | Binding affinity to NRAS RNA g-quadruplex (unknown origin) by fluorescence spectroscopy | Not specified | 3 | nucleic acid format | Scientific Literature | ||
4. | ALA4381087 | B | Binding affinity to human KRAS utr-1 RNA g-quadruplex by fluorescence spectroscopy | Homo sapiens | 3 | nucleic acid format | Scientific Literature | ||
5. | ALA4381088 | B | Binding affinity to human KRAS utr-c RNA g-quadruplex by fluorescence spectroscopy | Homo sapiens | 3 | nucleic acid format | Scientific Literature | ||
6. | ALA4381089 | B | Binding affinity to human KRAS utr-z RNA g-quadruplex by fluorescence spectroscopy | Homo sapiens | 3 | nucleic acid format | Scientific Literature | ||
7. | ALA4381091 | P | Aggregation property of compound at > 40 degree C | 2 | small-molecule physicochemical format | Scientific Literature | |||
8. | ALA4381093 | B | Binding affinity to NRAS RNA g-quadruplex (unknown origin) at 40 degree C by SPR analysis | Not specified | 4 | nucleic acid format | Scientific Literature | ||
9. | ALA4381094 | B | Binding affinity to human KRAS utr-z RNA g-quadruplex at 40 degree C by SPR analysis | Homo sapiens | 4 | nucleic acid format | Scientific Literature | ||
10. | ALA4381096 | B | Binding affinity to human KRAS utr-z RNA g-quadruplex assessed as compound-RNA complex stoichiometry ratio of 9:1 by Job's plot analysis | Homo sapiens | 1 | nucleic acid format | Scientific Literature | ||
11. | ALA4381100 | A | Drug uptake in human PANC1 cells at 5 uM after 16 hrs by FACS analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
12. | ALA4381101 | A | Drug uptake in human PANC1 cells at 5 uM after 2 hrs by FACS analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
13. | ALA4381102 | A | Drug localization in cytoplasm of human PANC1 cells at 5 uM after 6 hrs by Hoechst staining based confocal microscopy | Homo sapiens | 2 | subcellular format | Scientific Literature | ||
14. | ALA4381103 | A | Drug uptake in human PANC1 cells in presence of dynamin-inhibitor dynasore | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
15. | ALA4381104 | A | Drug uptake in human PANC1 cells at 5 uM and 4 degree C after 16 hrs by FACS analysis relative to 37 degree C | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
16. | ALA4381105 | A | Drug uptake in human HEK293 cells at 5 uM and 4 degree C after 16 hrs by FACS analysis relative to 37 degree C | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
17. | ALA4381122 | B | Inhibition of KRAS in human PANC1 cells assessed as decrease in KRAS mRNA level at 15 nM followed by 7.2 J/cm2 irradiation after 4 hrs by qRT-PCR analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
18. | ALA4381123 | B | Inhibition of NRAS in human PANC1 cells assessed as decrease in NRAS mRNA level at 15 nM followed by 7.2 J/cm2 irradiation after 4 hrs by qRT-PCR analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
19. | ALA4381124 | B | Inhibition of KRAS in human PANC1 cells assessed as downregulation of KRAS expression at 15 nM followed by 7.2 J/cm2 irradiation after 4 hrs by Western blot analysis (Rvb = 5 %) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
20. | ALA4381125 | B | Inhibition of NRAS in human PANC1 cells assessed as downregulation of NRAS expression at 15 nM followed by 7.2 J/cm2 irradiation after 4 hrs by Western blot analysis (Rvb = 25 %) | Homo sapiens | 2 | cell-based format | Scientific Literature |