| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4412490 | Binding | Inhibition of N-terminal His-tagged human TAK1 (1 to 303 amino acids)/human TAB1 (437 to 504 amino acids) expressed in baculovirus expression system using fluorescence-labeled substrate by off-chip mobility shift assay | Homo sapiens | 3 | ALA4411291 | assay format | Scientific Literature | |
| 2. | ALA4412494 | Binding | Inhibition of TAK1 (unknown origin) at 1 uM by LanthaScreen Eu kinase binding assay relative to control | Homo sapiens | 18 | ALA4411291 | single protein format | Scientific Literature | |
| 3. | ALA4412495 | Binding | Inhibition of TAK1 (unknown origin) at 0.1 uM by LanthaScreen Eu kinase binding assay relative to control | Homo sapiens | 18 | ALA4411291 | single protein format | Scientific Literature | |
| 4. | ALA4412496 | Functional | Growth inhibition of human SKCO1 cells after 96 hrs by SRB assay | Homo sapiens | 2 | ALA4411291 | cell-based format | Scientific Literature | |
| 5. | ALA4412497 | Functional | Growth inhibition of human SW620 cells after 96 hrs by SRB assay | Homo sapiens | 3 | ALA4411291 | cell-based format | Scientific Literature | |
| 6. | ALA4412498 | Functional | Growth inhibition of human LoVo cells after 96 hrs by SRB assay | Homo sapiens | 2 | ALA4411291 | cell-based format | Scientific Literature | |
| 7. | ALA4412499 | Functional | Induction of apoptosis in human SW620 cells assessed as Caspase-3 activity at 10 uM after 24 hrs by Caspase-3/7 reagent-based fluorescence assay | Homo sapiens | 1 | ALA4411291 | cell-based format | Scientific Literature | |
| 8. | ALA4412500 | Binding | Inhibition of TAK1 phosphorylation in human SW620 cells after 24 hrs by immunoblotting analysis | Homo sapiens | 1 | ALA4411291 | cell-based format | Scientific Literature | |
| 9. | ALA4412501 | ADME | Stability in human liver microsomes assessed as parent compound remaining after 60 mins in presence of NADPH by HPLC analysis | Homo sapiens | 2 | ALA4411291 | microsome format | Scientific Literature | |
| 10. | ALA4412502 | ADME | Stability in mouse liver microsomes assessed as parent compound remaining after 60 mins in presence of NADPH by HPLC analysis | Mus musculus | 2 | ALA4411291 | microsome format | Scientific Literature | |
| 11. | ALA4412503 | ADME | Stability in human plasma assessed as parent compound remaining after 6 hrs by LC-MS/MS analysis | Homo sapiens | 2 | ALA4411291 | cell-free format | Scientific Literature | |
| 12. | ALA4412504 | ADME | Stability in mouse plasma assessed as parent compound remaining after 6 hrs by LC-MS/MS analysis | Mus musculus | 2 | ALA4411291 | cell-free format | Scientific Literature | |
| 13. | ALA4412505 | ADME | AUC (0 to 7 hrs) in ICR mouse at 8.2 mg/kg, po administered as single dose or 3 mg/kg, iv by LC-MS/MS analysis | Mus musculus | 1 | ALA4411291 | organism-based format | Scientific Literature | |
| 14. | ALA4412506 | ADME | Cmax in ICR mouse at 8.2 mg/kg, po administered as single dose or 3 mg/kg, iv by LC-MS/MS analysis | Mus musculus | 1 | ALA4411291 | organism-based format | Scientific Literature | |
| 15. | ALA4412507 | ADME | Half life in ICR mouse at 8.2 mg/kg, po administered as single dose or 3 mg/kg, iv by LC-MS/MS analysis | Mus musculus | 1 | ALA4411291 | organism-based format | Scientific Literature | |
| 16. | ALA4412508 | ADME | Oral bioavailability in ICR mouse at 8.2 mg/kg administered as single dose by LC-MS/MS analysis | Mus musculus | 1 | ALA4411291 | organism-based format | Scientific Literature | |
| 17. | ALA4412513 | ADME | Inhibition of CYP3A4 in liver microsomes (unknown origin) using ketoconazole as substrate preincubated for 5 mins followed by NADPH addition and measured after 15 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA4411291 | microsome format | Scientific Literature | |
| 18. | ALA4412514 | ADME | Inhibition of CYP1A2 in liver microsomes (unknown origin) using alpha-naphthoflavone as substrate preincubated for 5 mins followed by NADPH addition and measured after 15 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA4411291 | microsome format | Scientific Literature | |
| 19. | ALA4412515 | ADME | Inhibition of CYP2C9 in liver microsomes (unknown origin) using sulfaphenazole as substrate preincubated for 5 mins followed by NADPH addition and measured after 15 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA4411291 | microsome format | Scientific Literature | |
| 20. | ALA4412516 | ADME | Inhibition of CYP2C19 in liver microsomes (unknown origin) using (+/-) N-3-benzylnirvanol as substrate preincubated for 5 mins followed by NADPH addition and measured after 15 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA4411291 | microsome format | Scientific Literature |
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