# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4398699 | B | Inhibition of bovine aortic smooth muscle PDE5 using cGMP as substrate incubated for 30 mins in presence of EGTA and [3H]cGMP by liquid scintillation counting method | Bos taurus | 74 | single protein format | Scientific Literature | ||
2. | ALA4398700 | B | Inhibition of bovine aortic smooth muscle PDE5 at 10 uM using cGMP as substrate incubated for 30 mins in presence of EGTA and [3H]cGMP by liquid scintillation counting method relative to control | Bos taurus | 81 | single protein format | Scientific Literature | ||
3. | ALA4398701 | B | Inhibition of bovine aortic smooth muscle PDE1 at 10 uM using cGMP as substrate incubated for 30 mins in presence of [3H]cGMP by liquid scintillation counting method relative to control | Bos taurus | 12 | assay format | Scientific Literature | ||
4. | ALA4398702 | B | Inhibition of human platelets PDE2 at 10 uM using cAMP as substrate incubated for 30 mins in presence of [3H]cAMP and cGMP by liquid scintillation counting method relative to control | Homo sapiens | 11 | assay format | Scientific Literature | ||
5. | ALA4398703 | B | Inhibition of bovine aortic smooth muscle PDE3 at 10 uM using cAMP as substrate incubated for 30 mins in presence of EGTA and [3H]cAMP by liquid scintillation counting method relative to control | Bos taurus | 4 | assay format | Scientific Literature | ||
6. | ALA4398708 | B | Inhibition of bovine aortic smooth muscle PDE4 at 10 uM using cAMP as substrate incubated for 30 mins in presence of EGTA and [3H]cAMP by liquid scintillation counting method | Bos taurus | 3 | assay format | Scientific Literature | ||
7. | ALA4398709 | B | Selectivity ratio of IC50 for inhibition of bovine aortic smooth muscle PDE4 to IC50 for inhibition of bovine aortic smooth muscle PDE5 | Bos taurus | 3 | assay format | Scientific Literature | ||
8. | ALA4398710 | P | Solubility of compound in saline at 0.040 to 4 umol/mL incubated for 24 hrs by HPLC/UV analysis | 9 | small-molecule physicochemical format | Scientific Literature | |||
9. | ALA4398711 | P | Stability of compound in methanol:water:HCl assessed as parent compound remaining at 0.040 to 4 umol/ml at pH 1 and measured for 96 hrs by HPLC/UV analysis relative to control | 14 | small-molecule physicochemical format | Scientific Literature | |||
10. | ALA4398712 | F | Antiallodynic activity in C57BL/6J mouse assessed as reduction in cuff-induced pain at 0.5 to 3 mg/kg, ip bid for 3 weeks administrated 2 weeks post cuff-insertion and measured after 15 days by Von Frey test | Mus musculus | 3 | organism-based format | Scientific Literature |