# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4476968 | B | Binding affinity to full-length human N-terminal His6-tagged Hint1 expressed in Escherichia coli Rosetta 2 pLysS cells by isothermal titration calorimetry | Homo sapiens | 12 | cell-based format | Patent Bioactivity Data | ||
2. | ALA4476969 | F | Analgesic activity in ICR mouse model of spared nerve injury assessed as reduction in mechanical hypersensitivity at 1 nmol administered intrathecally prior to spared nerve injury by Von Frey test | Mus musculus | 2 | organism-based format | Patent Bioactivity Data | ||
3. | ALA4476971 | F | Analgesic activity in ICR mouse model of spared nerve injury assessed as reduction in mechanical hypersensitivity at 1 nmol administered intrathecally 7 days post spared nerve injury measured after 4 hrs by Von Frey test | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
4. | ALA4476972 | F | Suppression of morphine-induced inhibition of NMDA-evoked mechanical hypersensitivity in ICR mouse administered intrathecally treated 10 mins prior to morphine addition followed by NMDA stimulation for 10 mins and measured for 1 min by tail flick test | Mus musculus | 3 | organism-based format | Patent Bioactivity Data | ||
5. | ALA4476973 | F | Suppression of morphine-induced analgesic tolerance in ICR mouse model of spared nerve injury-induced neuropathic pain assessed as reduction in mechanical hypersensitivity administered intrathecally for 3 days prior to morphine challenge on day 4 by Von Frey test | Mus musculus | 2 | organism-based format | Patent Bioactivity Data | ||
6. | ALA4476974 | F | Effect on spared nerve injury-induced ICR mouse model of neuropathic pain administered intrathecally for 3 days by Von Frey test | Mus musculus | 2 | organism-based format | Patent Bioactivity Data | ||
7. | ALA4476976 | P | Aqueous solubility of the compound | 4 | small-molecule physicochemical format | Patent Bioactivity Data | |||
8. | ALA4476978 | F | Suppression of morphine-induced analgesic tolerance in ICR mouse model of spared nerve injury-induced neuropathic pain assessed as reduction in mechanical hypersensitivity administered intrathecally for 3 days prior to morphine challenge on day 4 by Von Frey test relative to control | Mus musculus | 2 | organism-based format | Patent Bioactivity Data | ||
9. | ALA4476979 | F | Effect on spared nerve injury-induced ICR mouse model of neuropathic pain administered intrathecally for 3 days by Von Frey test relative to control | Mus musculus | 2 | organism-based format | Patent Bioactivity Data |