| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4400379 | A | Inhibition of CYP2C9 (unknown origin) | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 2. | ALA4400380 | A | Inhibition of CYP2C19 (unknown origin) | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 3. | ALA4400381 | A | Inhibition of CYP1A2 (unknown origin) | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 4. | ALA4400382 | B | Inhibition of endothelial lipase in human serum | Homo sapiens | 14 | cell-free format | Scientific Literature | ||
| 5. | ALA4400383 | A | Inhibition of hepatic lipase (unknown origin) | Homo sapiens | 14 | single protein format | Scientific Literature | ||
| 6. | ALA4400384 | B | Inhibition of endothelial lipase (unknown origin) | Homo sapiens | 14 | single protein format | Scientific Literature | ||
| 7. | ALA4400385 | F | Antiatherosclerotic in C57BL/6 mouse assessed as change in phospholipid level in plasma at 50 mg/kg, ip qd administrated for 2 days and measured 6 hrs post last dose by FPLC analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA4400386 | A | Inhibition of CYP2D6 (unknown origin) | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 9. | ALA4400387 | A | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 10. | ALA4400388 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining at 0.5 uM preincubated with compound followed by NADPH addition and measured after 10 mins | Homo sapiens | 5 | microsome format | Scientific Literature | ||
| 11. | ALA4400389 | A | Metabolic stability in mouse liver microsomes assessed as parent compound remaining at 0.5 uM preincubated with compound followed by NADPH addition and measured after 10 mins | Mus musculus | 5 | microsome format | Scientific Literature | ||
| 12. | ALA4400390 | A | Permeability of compound at pH 7.4 by PAMPA | 5 | assay format | Scientific Literature | |||
| 13. | ALA4400391 | A | Permeability of compound at pH 5.0 by PAMPA | 5 | assay format | Scientific Literature | |||
| 14. | ALA4400392 | A | Permeability across apical to basolateral side in human Caco2 cells | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 15. | ALA4400393 | A | Permeability across basolateral to apical side in human Caco2 cells | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 16. | ALA4400394 | B | Reversible inhibition of endothelial lipase (unknown origin) assessed as recovery of enzyme activity measured after 24 hrs by dialysis based assay relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 17. | ALA4400395 | A | Cmax in BALB/c mouse at 10 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4400396 | A | Tmax in BALB/c mouse at 10 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4400397 | A | AUC (0 to 24 hrs) in BALB/c mouse at 10 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4400398 | A | Half life in BALB/c mouse at 10 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!