| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4337280 | B | Inhibition of LPS-induced NFkappaB p65 nuclear translocation in mouse RAW264.7 cells at 5 to 50 uM preincubated for 2 hrs followed by LPS-stimulation after 22 hrs by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA4337281 | B | Inhibition of LPS-induced IKBalpha phosphorylation mouse RAW264.7 cells at 5 to 50 uM preincubated for 2 hrs followed by LPS-stimulation after 22 hrs by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA4337282 | F | Antiinflammatory activity against mouse RAW264.7 cells assessed as reduction in LPS-induced Cox2 protein expression compound preincubated for 2 hrs followed by LPS stimulation after 22 hrs by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA4337283 | F | Antiinflammatory activity against mouse RAW264.7 cells assessed as reduction in LPS-induced iNOS protein expression compound preincubated for 2 hrs followed by LPS stimulation after 22 hrs by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4337284 | F | Antiinflammatory activity against mouse RAW264.7 cells assessed as reduction in LPS-induced IL-1beta mRNA expression compound preincubated for 2 hrs followed by LPS stimulation after 22 hrs by RT-PCR analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4337285 | F | Antiinflammatory activity against mouse RAW264.7 cells assessed as reduction in LPS-induced Cox2 mRNA expression compound preincubated for 2 hrs followed by LPS stimulation after 22 hrs by RT-PCR analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4337286 | T | Toxicity in DBA/1J mouse assessed as effect on body weight at 50 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA4337287 | F | Antiinflammatory activity against mouse RAW264.7 cells assessed as reduction in LPS-induced iNOS mRNA expression compound preincubated for 2 hrs followed by LPS stimulation after 22 hrs by RT-PCR analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4337288 | T | Toxicity in DBA/1J mouse assessed as effect on behavioral changes at 50 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA4337289 | F | Antiarthritic activity in collagen-induced rheumatoid arthritis DBA/1J mouse model assessed as reduction in hindlimb swelling at 50 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA4337290 | F | Antiarthritic activity in collagen-induced rheumatoid arthritis DBA/1J mouse model assessed as reduction in forelimb swelling at 50 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA4337291 | F | Antiarthritic activity in collagen-induced rheumatoid arthritis DBA/1J mouse model at 50 mg/kg, po after 22 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4337293 | F | Antiinflammatory activity against carrageenan-induced paw oedema in ICR mouse assessed as reduction in NO level in serum at 50 mg/kg, po administered 30 mins prior to carrageenan challenge after 5 hrs post carrageenan | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA4337295 | F | Antiinflammatory activity against carrageenan-induced paw oedema in ICR mouse assessed as inhibition of paw edema at 50 mg/kg, po administered 30 mins prior to carrageenan challenge after 5 hrs post carrageenan challenge | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4337297 | A | Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay | Mus musculus | 14 | cell-based format | Scientific Literature | ||
| 16. | ALA4337298 | F | Antiinflammatory activity against carrageenan-induced paw edema in ICR mouse assessed as inhibition of paw edema at 50 mg/kg, po administered 30 mins prior to carrageenan challenge measured at 2 hrs post carrageenan challenge relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4337299 | F | Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 2 hrs followed by LPS stimulation and measured after 24 hrs by by Griess assay | Mus musculus | 14 | cell-based format | Scientific Literature | ||
| 18. | ALA4337300 | B | Inhibition of LPS-induced JNK phosphorylation in mouse RAW264.7 cells at 5 to 50 uM preincubated for 2 hrs followed by LPS-stimulation after 22 hrs by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4337301 | B | Inhibition of LPS-induced P38 phosphorylation in mouse RAW264.7 cells at 5 to 50 uM preincubated for 2 hrs followed by LPS-stimulation after 22 hrs by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4337302 | B | Inhibition of LPS-induced ERK phosphorylation in mouse RAW264.7 cells at 5 to 50 uM preincubated for 2 hrs followed by LPS-stimulation after 22 hrs by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature |
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