# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4325394 | Binding | Selectivity index, ratio of Kb for human DP1 transfected in rat C6 cells to Kb for human EP2 transfected in rat C6 cells | Homo sapiens | 18 | ALA4321875 | cell-based format | Scientific Literature | |
2. | ALA4325397 | Physicochemical | Aqueous solubility in PBS pH 7.4 incubated for 24 hrs by nephelometry | 44 | ALA4321875 | small-molecule physicochemical format | Scientific Literature | ||
3. | ALA4325398 | Functional | Antagonist activity at human EP2 transfected in rat C6 cells assessed as decrease in intracellular cAMP incubated for 10 mins followed by PGE2 addition and measured after 40 mins by TR-FRET assay | Homo sapiens | 46 | ALA4321875 | cell-based format | Scientific Literature | |
4. | ALA4325402 | Functional | Antagonist activity at human DP1 transfected in rat C6 cells assessed as decrease in intracellular cAMP incubated for 10 mins followed by PGE2 addition and measured after 40 mins by TR-FRET assay | Homo sapiens | 17 | ALA4321875 | cell-based format | Scientific Literature | |
5. | ALA4325403 | Functional | Antagonist activity at human EP4 transfected in rat C6 cells assessed as decrease in intracellular cAMP incubated for 10 mins followed by PGE2 addition and measured after 40 mins by TR-FRET assay | Homo sapiens | 17 | ALA4321875 | cell-based format | Scientific Literature | |
6. | ALA4325404 | Binding | Selectivity index, ratio of Kb for human EP4 transfected in rat C6 cells to Kb for human EP2 transfected in rat C6 cells | Homo sapiens | 12 | ALA4321875 | cell-based format | Scientific Literature | |
7. | ALA4325405 | Functional | Antagonist activity at human IP transfected in rat C6 cells assessed as decrease in intracellular cAMP incubated for 10 mins followed by PGE2 addition and measured after 40 mins by TR-FRET assay | Homo sapiens | 17 | ALA4321875 | cell-based format | Scientific Literature | |
8. | ALA4325406 | Binding | Selectivity index, ratio of Kb for human IP transfected in rat C6 cells to Kb for human EP2 transfected in rat C6 cells | Homo sapiens | 12 | ALA4321875 | cell-based format | Scientific Literature | |
9. | ALA4325407 | ADME | Cytotoxicity against rat C6 cells assessed as reduction in cell viability | Rattus norvegicus | 17 | ALA4321875 | cell-based format | Scientific Literature |