| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4325426 | B | Binding affinity to p300 in human MV4-11 cells assessed as stabilization of protein measured after 12 hrs by CETSA | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA4325427 | B | Inhibition of p300 (unknown origin) using histone H3 (1 to 21 residues) as substrate preincubated for 15 mins followed by substrate and [3H]acetyl-CoA addition and measured after 60 mins by scintillation counting analysis | Homo sapiens | 28 | single protein format | Scientific Literature | ||
| 3. | ALA4325428 | F | Antiproliferative activity against human MV4-11 cells measured after 3 days by celltiter-glo luminescence assay | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
| 4. | ALA4325429 | A | Intrinsic clearance in human liver microsomes assessed per mg protein at 0.1 uM preincubated for 10 mins followed by NADPH addition and measured up to 60 mins by UPLC-MS/MS analysis | Homo sapiens | 28 | microsome format | Scientific Literature | ||
| 5. | ALA4325430 | A | Intrinsic clearance in rat liver microsomes assessed per mg protein at 0.1 uM preincubated for 10 mins followed by NADPH addition and measured up to 60 mins by UPLC-MS/MS analysis | Rattus norvegicus | 28 | microsome format | Scientific Literature | ||
| 6. | ALA4325431 | A | Intrinsic clearance in mouse liver microsomes assessed per mg protein at 0.1 uM preincubated for 10 mins followed by NADPH addition and measured up to 60 mins by UPLC-MS/MS analysis | Mus musculus | 28 | microsome format | Scientific Literature | ||
| 7. | ALA4325432 | A | Half life in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
| 8. | ALA4325433 | A | Volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
| 9. | ALA4325434 | A | AUClast in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
| 10. | ALA4325435 | A | Clearance in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
| 11. | ALA4325436 | A | Half life in Sprague-Dawley rat at 3 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 9 | organism-based format | Scientific Literature | ||
| 12. | ALA4325437 | A | Tmax in Sprague-Dawley rat at 3 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 9 | organism-based format | Scientific Literature | ||
| 13. | ALA4325438 | A | Cmax in Sprague-Dawley rat at 3 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 9 | organism-based format | Scientific Literature | ||
| 14. | ALA4325439 | A | AUClast in Sprague-Dawley rat at 3 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 9 | organism-based format | Scientific Literature | ||
| 15. | ALA4325440 | A | Oral bioavailability in Sprague-Dawley rat at 3 mg/kg by LC-MS/MS analysis | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
| 16. | ALA4325441 | A | Protein binding in rat plasma | Rattus norvegicus | 4 | cell-free format | Scientific Literature | ||
| 17. | ALA4325442 | B | Inhibition of HAT1 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 18. | ALA4325443 | B | Inhibition of GCN5 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 19. | ALA4325444 | B | Inhibition of NatD (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 20. | ALA4325445 | B | Inhibition of PCAF (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature |
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