| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4354244 | B | Inhibition of recombinant human N-terminal GST-tagged ROS1 (catalytic domain 1883 - 2347 residues) expressed in baculovirus system assessed as decrease in substrate phosphorylation using TK peptide as substrate preincubated with enzyme for 30 mins followed by substrate addition by HTRF method | Homo sapiens | 20 | assay format | Scientific Literature | ||
| 2. | ALA4354245 | B | Inhibition of recombinant human N-terminal GST-tagged ALK (catalytic domain 1058 - 1620 residues) expressed in baculovirus system assessed as decrease in substrate phosphorylation using TK peptide as substrate preincubated with enzyme for 30 mins followed by substrate addition by HTRF method | Homo sapiens | 20 | assay format | Scientific Literature | ||
| 3. | ALA4354246 | B | Inhibition of recombinant human N-terminal GST-tagged ALK (catalytic domain 1058 - 1620 residues) expressed in baculovirus system assessed as decrease in substrate phosphorylation using TK peptide as substrate at 1 uM preincubated with enzyme for 30 mins followed by substrate addition by HTRF method relative to control | Homo sapiens | 20 | assay format | Scientific Literature | ||
| 4. | ALA4354247 | B | Inhibition of recombinant human N-terminal GST-tagged ROS1 (catalytic domain 1883 - 2347 residues) expressed in baculovirus system assessed as decrease in substrate phosphorylation using TK peptide as substrate at 1 uM preincubated with enzyme for 30 mins followed by substrate addition by HTRF method relative to control | Homo sapiens | 20 | assay format | Scientific Literature | ||
| 5. | ALA4354248 | F | Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
| 6. | ALA4354249 | F | Antiproliferative activity against ALK-addicted human NCI-H3122 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
| 7. | ALA4354250 | F | Antiproliferative activity against ROS1-addicted human HCC78 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 20 | cell-based format | Scientific Literature |
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