| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4356260 | T | Toxicity in Swiss mouse model of amyloid-beta (25 to 35)-induced Alzheimer disease assessed as reduction in body weight at 0.3 to 3 mg/kg, ip administered 20 mins after amyloid-beta (25 to 35) stimulation for 7 days and observed on day 11 | Mus musculus | 5 | ALA4354814 | organism-based format | Scientific Literature | |
| 2. | ALA4356262 | B | Inhibition of human BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured for 3 mins by spectrophotometry based Ellman's method | Homo sapiens | 17 | ALA4354814 | single protein format | Scientific Literature | |
| 3. | ALA4356264 | B | Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured for 3 mins by spectrophotometry based Ellman's method | Homo sapiens | 17 | ALA4354814 | single protein format | Scientific Literature | |
| 4. | ALA4356266 | F | Cognitive enhancing effect in Swiss mouse model of amyloid-beta (25 to 35)-induced Alzheimer disease assessed as shock sensitivity at 1 mg/kg, ip administered 20 mins after amyloid-beta (25 to 35) stimulation for 7 days and observed on day 10 by passive avoidance test (Rvb = 1.4 +/- 0.3 No_unit) | Mus musculus | 1 | ALA4354814 | organism-based format | Scientific Literature | |
| 5. | ALA4356272 | B | Selectivity index, ratio of pIC50 for recombinant human AChE to pIC50 for human BChE | Homo sapiens | 15 | ALA4354814 | protein format | Scientific Literature | |
| 6. | ALA4356276 | B | Displacement of [3H]-CP55940 from human recombinant cannabinoid CB2 receptor expressed in human HEK cells by radioligand binding assay | Homo sapiens | 16 | ALA4354814 | cell-based format | Scientific Literature | |
| 7. | ALA4356279 | B | Displacement of [3H]-CP55940 from human recombinant cannabinoid CB1 receptor expressed in CHO cells at 10 uM by radioligand binding assay relative to control | Homo sapiens | 16 | ALA4354814 | cell-based format | Scientific Literature | |
| 8. | ALA4356287 | F | Immunomodulatory activity in mouse N9 cells assessed as reduction in LPS-induced nitrite accumulation incubated for 24 hrs by Griess reagent based colorimetry assay | Mus musculus | 3 | ALA4354814 | cell-based format | Scientific Literature | |
| 9. | ALA4356288 | F | Immunomodulatory activity in mouse N9 cells assessed as reduction in LPS-induced IL-1beta release incubated for 24 hrs by Western blot analysis | Mus musculus | 3 | ALA4354814 | cell-based format | Scientific Literature | |
| 10. | ALA4356289 | F | Immunomodulatory activity in mouse N9 cells assessed as reduction in LPS-induced iNOS expression incubated for 24 hrs by Western blot analysis | Mus musculus | 3 | ALA4354814 | cell-based format | Scientific Literature | |
| 11. | ALA4356290 | F | Immunomodulatory activity in mouse N9 cells assessed as effect on LPS-induced TREM2 expression at 1 to 5 uM incubated for 24 hrs by Western blot analysis | Mus musculus | 3 | ALA4354814 | cell-based format | Scientific Literature | |
| 12. | ALA4356291 | F | Immunomodulatory activity in mouse N9 cells assessed as reduction in LPS-induced TGFbeta2 expression incubated for 24 hrs by Western blot analysis | Mus musculus | 3 | ALA4354814 | cell-based format | Scientific Literature | |
| 13. | ALA4356296 | T | Neurotoxicity against mouse HT22 cells assessed as cell viability at 5 uM incubated for 24 hrs by MTT assay | Mus musculus | 2 | ALA4354814 | cell-based format | Scientific Literature | |
| 14. | ALA4356298 | F | Cognitive enhancing effect in Swiss mouse model of amyloid-beta (25 to 35)-induced Alzheimer disease assessed as reduction in spontaneous alteration score at 0.3 to 3 mg/kg, ip administered 20 mins after amyloid-beta (25 to 35) stimulation for 7 days and observed on day 11 by Y-maze test | Mus musculus | 3 | ALA4354814 | organism-based format | Scientific Literature | |
| 15. | ALA4356300 | T | Hepatotoxicity in Swiss mouse model of amyloid-beta (25 to 35)-induced Alzheimer disease assessed as microvesicular-steatotis incidence level at 3 mg/kg, ip administered 20 mins after amyloid-beta (25 to 35) stimulation for 7 days and observed on day 11 by hematoxylin-eosin staining based assay (Rvb = 58%) | Mus musculus | 4 | ALA4354814 | organism-based format | Scientific Literature | |
| 16. | ALA4356301 | T | Hepatotoxicity in Swiss mouse model of amyloid-beta (25 to 35)-induced Alzheimer disease assessed as microvesicular-steatotis area level at 3 mg/kg, ip administered 20 mins after amyloid-beta (25 to 35) stimulation for 7 days and observed on day 11 by hematoxylin-eosin staining based assay (Rvb = 10 to 30%) | Mus musculus | 4 | ALA4354814 | organism-based format | Scientific Literature | |
| 17. | ALA4356302 | T | Hepatotoxicity in Swiss mouse model of amyloid-beta (25 to 35)-induced Alzheimer disease assessed as necrosis incidence level at 3 mg/kg, ip administered 20 mins after amyloid-beta (25 to 35) stimulation for 7 days and observed on day 11 by hematoxylin-eosin staining based assay (Rvb = 91%) | Mus musculus | 4 | ALA4354814 | organism-based format | Scientific Literature | |
| 18. | ALA4356303 | T | Hepatotoxicity in Swiss mouse model of amyloid-beta (25 to 35)-induced Alzheimer disease assessed as necrosis area level at 3 mg/kg, ip administered 20 mins after amyloid-beta (25 to 35) stimulation for 7 days and observed on day 11 by hematoxylin-eosin staining based assay (Rvb = 1 to 30%) | Mus musculus | 4 | ALA4354814 | organism-based format | Scientific Literature |
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