| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4337893 | B | Binding affinity to Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease assessed as change in melting temperature at 200 uM using SYPRO orange dye by DSF based thermal shift assay | Influenza A virus | 22 | single protein format | Scientific Literature | ||
| 2. | ALA4337894 | B | Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease using [6-FAM]AATCGCAGGCAGCACTC[TAM] substrate and measured over 45 mins by fluorescence based assay | Influenza A virus | 22 | single protein format | Scientific Literature | ||
| 3. | ALA4337898 | F | Antiviral activity against Influenza A virus (A/California/04/2009(H1N1)) ATCC VR-1737 infected in MDCK cells assessed as reduction in virus-induced cytopathic effect incubated for 48 hrs by Cell-titer-Glo luminescence assay | Influenza A virus (A/California/04/2009(H1N1)) | 6 | cell-based format | Scientific Literature | ||
| 4. | ALA4337899 | A | Cytotoxicity in MDCK cells assessed as reduction in cell viability incubated for 12 hrs by MTT assay | Canis lupus familiaris | 6 | cell-based format | Scientific Literature | ||
| 5. | ALA4337900 | A | Cytotoxicity in mouse NIH/3T3 cells assessed as reduction in cell viability incubated for 12 hrs by MTT assay | Mus musculus | 6 | cell-based format | Scientific Literature | ||
| 6. | ALA4337901 | T | Selectivity index, ratio of CC50 for cytotoxicity in MDCK cells assessed as reduction in cell viability incubated for 12 hrs by MTT assay to EC50 for antiviral activity against Influenza A virus (A/California/04/2009(H1N1)) ATCC VR-1737 infected in MDCK cells assessed as reduction in virus-induced cytopathic effect incubated for 48 hrs by Cell-titer-Glo luminescence assay | 5 | cell-based format | Scientific Literature | |||
| 7. | ALA4337902 | T | Selectivity index, ratio of CC50 for cytotoxicity in mouse NIH/3T3 cells assessed as reduction in cell viability incubated for 12 hrs by MTT assay to EC50 for antiviral activity against Influenza A virus (A/California/04/2009(H1N1)) ATCC VR-1737 infected in MDCK cells assessed as reduction in virus-induced cytopathic effect incubated for 48 hrs by Cell-titer-Glo luminescence assay | 5 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!