| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4376102 | A | Stability in mouse liver microsomes assessed as parent compound remaining measured after 30 mins | Mus musculus | 3 | microsome format | Scientific Literature | ||
| 2. | ALA4376103 | B | Inhibition of recombinant human N-terminal His6-tagged glutaminyl cyclase (Ala33 to Leu361 residues) expressed in baculovirus infected Sf21 insect cells using H-Gln-AMC hydrobromide as substrate measured in presence of pGAPase by fluorometric assay | Homo sapiens | 68 | cell-based format | Scientific Literature | ||
| 3. | ALA4376104 | A | Cytotoxicity against mouse HT22 cells assessed as cell viability at 10 uM measured after 18 hrs by MTT assay relative to control | Mus musculus | 24 | cell-based format | Scientific Literature | ||
| 4. | ALA4376105 | B | Displacement of tracer red from human ERG at 10 uM by fluorescence polarization assay relative to control | Homo sapiens | 23 | single protein format | Scientific Literature | ||
| 5. | ALA4376106 | F | Neuroprotection in human amyloid beta (3 to 40 residues)-induced ICR mouse model of Alzheimer's disease assessed as inhibition of human amyloid beta N3pE-40 level in brain at 25 mg/kg, icv measured after 24 hrs by sandwich ELISA relative to control | Mus musculus | 24 | organism-based format | Scientific Literature | ||
| 6. | ALA4376107 | F | Neuroprotection in human amyloid beta (3 to 40 residues)-induced ICR mouse model of Alzheimer's disease assessed as inhibition of human amyloid beta N3pE-40 level in brain at 25 mg/kg, ip measured after 24 hrs by sandwich ELISA relative to control | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 7. | ALA4376108 | A | Stability in human liver microsomes assessed as parent compound remaining measured after 30 mins | Homo sapiens | 3 | microsome format | Scientific Literature | ||
| 8. | ALA4376109 | B | Inhibition of isoQC (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 9. | ALA4376110 | B | Selectivity ratio of IC50 for isoQC (unknown origin) to IC50 for recombinant human N-terminal His6-tagged glutaminyl cyclase (Ala33 to Leu361 residues) expressed in baculovirus infected Sf21 insect cells | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4376111 | B | Inhibition of mouse glutaminyl cyclase | Mus musculus | 1 | single protein format | Scientific Literature | ||
| 11. | ALA4376112 | F | Antialzheimer activity in 5XFAD transgenic ICR mouse assessed as reduction in amyloid beta N3pE-40 level in brain at 25 mg/kg, ip administered daily for 4 weeks measured post-last dose by sandwich ELISA relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA4376113 | F | Antialzheimer activity in 5XFAD transgenic ICR mouse assessed as reduction in amyloid beta N3pE-42 level in brain at 25 mg/kg, ip administered daily for 4 weeks measured post-last dose by sandwich ELISA relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4376114 | F | Antialzheimer activity in 5XFAD transgenic ICR mouse assessed as reduction in amyloid beta-40 level in brain at 25 mg/kg, ip administered daily for 4 weeks measured post-last dose by sandwich ELISA relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA4376115 | F | Antialzheimer activity in 5XFAD transgenic ICR mouse assessed as reduction in amyloid beta-42 level in brain at 25 mg/kg, ip administered daily for 4 weeks measured post-last dose by sandwich ELISA relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4376116 | T | Toxicity in 5XFAD transgenic ICR mouse at 25 mg/kg, ip administered daily for 4 weeks | Mus musculus | 1 | organism-based format | Scientific Literature |
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