# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4324918 | Functional | Agonist activity at mouse mu opioid receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP formation incubated for 8 min followed by forskolin stimulation by ELISA | Mus musculus | 4 | ALA4321862 | cell-based format | Scientific Literature | |
2. | ALA4324921 | Binding | Displacement of [3H]-Naloxone from mouse mu opioid receptor expressed in CHO cells incubated for 1.5 hrs by competitive radioligand binding assay | Mus musculus | 25 | ALA4321862 | cell-based format | Scientific Literature | |
3. | ALA4324922 | ADME | Displacement of [3H]-Naltrindole from mouse kappa opioid receptor expressed in CHO cells incubated for 1.5 hrs by competitive radioligand binding assay | Mus musculus | 24 | ALA4321862 | cell-based format | Scientific Literature | |
4. | ALA4324923 | ADME | Displacement of [3H]-norBNI from human delta opioid receptor expressed in CHO cells incubated for 1.5 hrs by competitive radioligand binding assay | Homo sapiens | 24 | ALA4321862 | cell-based format | Scientific Literature | |
5. | ALA4324924 | Unassigned | Selectivity index, ratio of Ki for mouse kappa opioid receptor expressed in CHO cells to Ki for mouse mu opioid receptor expressed in CHO cells | Mus musculus | 25 | ALA4321862 | cell-based format | Scientific Literature | |
6. | ALA4324925 | Unassigned | Selectivity index, ratio of Ki for human delta opioid receptor expressed in CHO cells to Ki for mouse mu opioid receptor expressed in CHO cells | Mus musculus | 24 | ALA4321862 | cell-based format | Scientific Literature | |
7. | ALA4324926 | Functional | Agonist activity at recombinant mouse mu opioid receptor expressed in CHO cell membrane assessed as [35]-GTPgammaS binding incubated for 1.5 hrs by scintillation counting method | Mus musculus | 25 | ALA4321862 | cell-based format | Scientific Literature | |
8. | ALA4324927 | Functional | Agonist activity at recombinant mouse mu opioid receptor expressed in CHO cell membrane assessed as [35]-GTPgammaS binding incubated for 1.5 hrs by scintillation counting method relative to DAMGO | Mus musculus | 25 | ALA4321862 | cell-based format | Scientific Literature | |
9. | ALA4324930 | Functional | Inhibition of morphine-induced antinociceptive activity in Swiss Webster mouse assessed as decrease in latency to tail withdrawal at 10 mg/kg, sc administered 5 mins before morphine stimulation observed for 20 mins by warm water tail withdrawal assay | Mus musculus | 7 | ALA4321862 | organism-based format | Scientific Literature | |
10. | ALA4324931 | Functional | Inhibition of morphine-induced antinociceptive activity in subcutaneously dosed Swiss Webster mouse assessed as decrease in latency to tail withdrawal administered 5 mins before morphine stimulation observed for 20 mins by warm water tail withdrawal assay | Mus musculus | 8 | ALA4321862 | organism-based format | Scientific Literature | |
11. | ALA4324932 | Functional | Agonist activity at mouse mu opioid receptor expressed in CHO cells cotransfected with Galphaqi5 assessed as intracellular calcium level preincubated for 60 mins in Fluo4AM solution followed by compound addition by Fluo4AM dye based assay | Mus musculus | 3 | ALA4321862 | cell-based format | Scientific Literature | |
12. | ALA4324933 | Functional | Antagonist activity at mouse mu opioid receptor expressed in CHO cells cotransfected with Galphaqi5 assessed as inhibition of DAMGO-induced increase in intracellular calcium concentration preincubated for 60 mins in Fluo4AM solution followed by compound addition and further incubated for 15 mins followed by DAMGO stimulation by Fluo4AM dye based assay | Mus musculus | 4 | ALA4321862 | cell-based format | Scientific Literature | |
13. | ALA4324934 | Functional | Agonist activity at mouse mu opioid receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP formation incubated for 8 min followed by forskolin stimulation by ELISA (Rvb = 0 %) | Mus musculus | 4 | ALA4321862 | cell-based format | Scientific Literature | |
14. | ALA4324938 | Functional | Inhibition of opioid-withdrawal symptom in morphine-pelleted Swiss Webster mouse assessed as reduction in wet dog shakes at 1 mg/kg, sc observed after 20 mins | Mus musculus | 4 | ALA4321862 | organism-based format | Scientific Literature | |
15. | ALA4324939 | Functional | Inhibition of opioid-withdrawal symptom in morphine-pelleted Swiss Webster mouse assessed as reduction in escape jumps at 1 mg/kg, sc observed after 20 mins | Mus musculus | 4 | ALA4321862 | organism-based format | Scientific Literature | |
16. | ALA4324940 | Functional | Inhibition of opioid-withdrawal symptom in morphine-pelleted Swiss Webster mouse assessed as reduction in paw tremors at 1 mg/kg, sc observed after 20 mins | Mus musculus | 4 | ALA4321862 | organism-based format | Scientific Literature | |
17. | ALA4324941 | Functional | Inhibition of opioid-withdrawal symptom in morphine-pelleted Swiss Webster mouse assessed as reduction in wet dog shakes at 8 mg/kg, sc observed after 20 mins | Mus musculus | 1 | ALA4321862 | organism-based format | Scientific Literature | |
18. | ALA4324942 | Functional | Inhibition of opioid-withdrawal symptom in morphine-pelleted Swiss Webster mouse assessed as reduction in escape jumps at 8 mg/kg, sc observed after 20 mins | Mus musculus | 1 | ALA4321862 | organism-based format | Scientific Literature | |
19. | ALA4324943 | Functional | Inhibition of opioid-withdrawal symptom in morphine-pelleted Swiss Webster mouse assessed as reduction in paw tremors at 8 mg/kg, sc observed after 20 mins | Mus musculus | 1 | ALA4321862 | organism-based format | Scientific Literature |