# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4403811 | B | Activation of human Kv7.2 expressed in CHO cells assessed as increase in current amplitude at 10 uM measured at holding potential of 0 mV by whole cell patch clamp electrophysiology assay relative to control | Homo sapiens | 45 | cell-based format | Scientific Literature | ||
2. | ALA4403812 | B | Activation of human Kv7.2 expressed in CHO cells assessed as increase in current amplitude at 10 uM measured at holding potential of -40 mV by whole cell patch clamp electrophysiology assay relative to control | Homo sapiens | 45 | cell-based format | Scientific Literature | ||
3. | ALA5113160 | B | Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation using arachidonic acid as substrate preincubated with enzyme for 15 mins followed by substrate addition and measured after 10 mins by RP-HPLC analysis | Homo sapiens | 21 | assay format | Scientific Literature | ||
4. | ALA5113161 | B | Inhibition of 5-LOX in human PMNL assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation preincubated for 15 mins followed by A23187 addition and measured after 10 mins by RP-HPLC analysis | Homo sapiens | 27 | cell-based format | Scientific Literature | ||
5. | ALA5113162 | B | Inhibition of human recombinant sEH assessed as reduction in 6-methoxynaphthaldehyde formation using PHOME as substrate preincubated for 1 min followed by substrate addition and measured after 60 mins by fluorescence based analysis | Homo sapiens | 20 | single protein format | Scientific Literature |