# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4373082 | B | Inhibition of PDE2 (unknown origin) using [3H]cAMP or [3H]cGMP as substrate measured after 30 mins by liquid scintillation counting method | Homo sapiens | 22 | ALA4371070 | single protein format | Scientific Literature | |
2. | ALA4373083 | A | Inhibition of PDE1 (unknown origin) using [3H]cAMP or [3H]cGMP as substrate measured after 30 mins by liquid scintillation counting method | Homo sapiens | 2 | ALA4371070 | protein format | Scientific Literature | |
3. | ALA4373084 | B | Inhibition of PDE4 (unknown origin) using [3H]cAMP or [3H]cGMP as substrate measured after 30 mins by liquid scintillation counting method | Homo sapiens | 2 | ALA4371070 | protein format | Scientific Literature | |
4. | ALA4373085 | B | Inhibition of PDE5 (unknown origin) using [3H]cAMP or [3H]cGMP as substrate measured after 30 mins by liquid scintillation counting method | Homo sapiens | 2 | ALA4371070 | single protein format | Scientific Literature | |
5. | ALA4373086 | B | Inhibition of PDE9 (unknown origin) using [3H]cAMP or [3H]cGMP as substrate measured after 30 mins by liquid scintillation counting method | Homo sapiens | 2 | ALA4371070 | single protein format | Scientific Literature | |
6. | ALA4373087 | B | Inhibition of PDE10 (unknown origin) using [3H]cAMP or [3H]cGMP as substrate measured after 30 mins by liquid scintillation counting method | Homo sapiens | 2 | ALA4371070 | single protein format | Scientific Literature | |
7. | ALA4373088 | B | Selectivity ratio of IC50 for PDE1 (unknown origin) to IC50 for PDE2 (unknown origin) | Homo sapiens | 2 | ALA4371070 | assay format | Scientific Literature | |
8. | ALA4373089 | B | Selectivity ratio of IC50 for PDE4 (unknown origin) to IC50 for PDE2 (unknown origin) | Homo sapiens | 2 | ALA4371070 | assay format | Scientific Literature | |
9. | ALA4373090 | B | Selectivity ratio of IC50 for PDE5 (unknown origin) to IC50 for PDE2 (unknown origin) | Homo sapiens | 2 | ALA4371070 | protein format | Scientific Literature | |
10. | ALA4373091 | B | Selectivity ratio of IC50 for PDE10 (unknown origin) to IC50 for PDE2 (unknown origin) | Homo sapiens | 2 | ALA4371070 | assay format | Scientific Literature | |
11. | ALA4373092 | F | Neuroprotective activity against corticosterone-induced toxicity in mouse HT22 cells assessed as increase in cell viability at 0.01 to 1 uM after 24 hrs by MTS assay | Mus musculus | 2 | ALA4371070 | cell-based format | Scientific Literature | |
12. | ALA4373093 | B | Inhibition of PDE2 in mouse HT22 cells assessed as suppression of corticosterone-induced decrease in cGMP level at 0.01 to 1 uM after 24 hrs by ELISA | Mus musculus | 1 | ALA4371070 | cell-based format | Scientific Literature | |
13. | ALA4373094 | B | Inhibition of PDE2 in mouse HT22 cells assessed as suppression of corticosterone-induced decrease in cAMP level at 0.01 to 1 uM after 24 hrs by ELISA | Mus musculus | 1 | ALA4371070 | cell-based format | Scientific Literature | |
14. | ALA4373097 | F | Anxiolytic activity in ICR mouse model of chronic stress-induced cognitive impairment assessed as increase in time spent in open arms administered via ig gavage measured for 5 mins test period by elevated plus maze test | Mus musculus | 1 | ALA4371070 | organism-based format | Scientific Literature | |
15. | ALA4373100 | T | Toxicity in ICR mouse assessed as effect on locomotory activity at 0.5 to 2 mg/kg, ig administered as single dose via gavage measured for 10 mins | Mus musculus | 1 | ALA4371070 | organism-based format | Scientific Literature | |
16. | ALA4373101 | A | Half life in ICR mouse at 2 mg/kg, po by LC-MS/MS analysis | Mus musculus | 1 | ALA4371070 | organism-based format | Scientific Literature | |
17. | ALA4373102 | A | Tmax in ICR mouse at 2 mg/kg, po by LC-MS/MS analysis | Mus musculus | 1 | ALA4371070 | organism-based format | Scientific Literature | |
18. | ALA4373103 | A | Cmax in ICR mouse at 2 mg/kg, po by LC-MS/MS analysis | Mus musculus | 1 | ALA4371070 | organism-based format | Scientific Literature | |
19. | ALA4373104 | A | AUC (0 to infinity) in ICR mouse at 2 mg/kg, po by LC-MS/MS analysis | Mus musculus | 1 | ALA4371070 | organism-based format | Scientific Literature | |
20. | ALA4373105 | A | Ratio of drug level in ICR mouse brain to plasma at 2 mg/kg, po measured after 0.5 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA4371070 | organism-based format | Scientific Literature |