# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4308758 | B | Inhibition of His-tagged/GST-tagged LCK (unknown origin) incubated for 1 hr by TR-FRET assay | Homo sapiens | 14 | single protein format | Scientific Literature | ||
2. | ALA4308759 | B | Inhibition of His-tagged/GST-tagged CSK (unknown origin) incubated for 1 hr by TR-FRET assay | Homo sapiens | 14 | single protein format | Scientific Literature | ||
3. | ALA4308760 | B | Effect on ZAP70 phosphorylation in human Jurkat cells pre-incubated for 30 mins followed by anti-CD3/CD28 stimulation measured after 10 mins | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
4. | ALA4308761 | B | Effect on ZAP70 phosphorylation in human Jurkat cells pre-incubated for 30 mins followed by anti-CD3/CD28 stimulation measured after 10 mins relative to control | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
5. | ALA4308762 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 0.5 uM measured after 10 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 14 | microsome format | Scientific Literature | ||
6. | ALA4308763 | A | Metabolic stability in mouse liver microsomes assessed as compound remaining at 0.5 uM measured after 10 mins in presence of NADPH by LC-MS/MS analysis | Mus musculus | 14 | microsome format | Scientific Literature | ||
7. | ALA4308765 | A | Half life in human liver microsomes at 0.5 uM measured up to 45 mins by LC-MS/MS analysis | Homo sapiens | 4 | microsome format | Scientific Literature | ||
8. | ALA4308766 | A | Half life in mouse liver microsomes at 0.5 uM measured up to 45 mins by LC-MS/MS analysis | Mus musculus | 4 | microsome format | Scientific Literature | ||
9. | ALA4308767 | A | Protein binding in human serum assessed as unbound fraction measured up to 5 hrs by LC-MS/MS analysis relative to control | Homo sapiens | 4 | cell-free format | Scientific Literature | ||
10. | ALA4308768 | A | Protein binding in mouse serum assessed as unbound fraction measured up to 5 hrs by LC-MS/MS analysis relative to control | Mus musculus | 4 | cell-free format | Scientific Literature | ||
11. | ALA4308769 | A | Cmax in C57BL/6 mouse at 100 mg/kg, po | Mus musculus | 2 | organism-based format | Scientific Literature | ||
12. | ALA4308770 | A | Tmax in C57BL/6 mouse at 100 mg/kg, po | Mus musculus | 2 | organism-based format | Scientific Literature | ||
13. | ALA4308771 | A | AUC in C57BL/6 mouse at 100 mg/kg, po | Mus musculus | 2 | organism-based format | Scientific Literature | ||
14. | ALA4308772 | F | Invivo inhibition of CSK in C57BL/6 mouse assessed as effect on LCK phosphorylation at Y505 residues in spleen at 100 mg/kg, po after 3 hrs relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
15. | ALA4308774 | A | Plasma concentration in C57BL/6 mouse at 100 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
16. | ALA4308777 | A | Drug concentration in C57BL/6 mouse at 100 mg/kg, po after 24 hrs | Mus musculus | 2 | organism-based format | Scientific Literature | ||
17. | ALA4308778 | A | Half life in C57BL/6 mouse at 100 mg/kg, po | Mus musculus | 2 | organism-based format | Scientific Literature |