# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4416169 | F | Antiplasmodial activity against Plasmodium falciparum 3D7A erythrocytic stage assessed as reduction in [3H]hypoxanthine incorporation preincubated for 24 hrs followed by [3H]hypoxanthine addition and measured after 24 hrs by microbeta scintillation counting method | Plasmodium falciparum | 59 | organism-based format | Scientific Literature | ||
2. | ALA4416170 | B | Inhibition of Plasmodium falciparum full length N-terminal His-tagged PKG expressed in Escherichia coli RosettaTM 2(DE3) pLysS cells using FAM-GRTGRRNSI-NH2 as substrate preincubated for 30 mins followed by ATP addition and measured after 30 mins by microfluidic mobility shift assay | Plasmodium falciparum | 57 | cell-based format | Scientific Literature | ||
3. | ALA4416171 | P | Lipophilicity, LogD of compound by reverse phase HPLC analysis | 57 | small-molecule physicochemical format | Scientific Literature | |||
4. | ALA4416172 | P | Aqueous solubility of compound | 57 | small-molecule physicochemical format | Scientific Literature | |||
5. | ALA4416173 | B | Inhibition of human ERG expressed in CHO cells by Q-patch clamp assay | Homo sapiens | 40 | cell-based format | Scientific Literature | ||
6. | ALA4416174 | A | Cytotoxicity against mouse L929 cells assessed as reduction in viability by dual luciferase reporter gene assay | Mus musculus | 57 | cell-based format | Scientific Literature | ||
7. | ALA4416175 | A | Permeability of compound by PAMPA | 57 | assay format | Scientific Literature | |||
8. | ALA4416176 | A | Clearance in mouse liver microsomes at 0.5 uM measured up to 45 mins in presence of NADPH by HPLC-MS/MS analysis | Mus musculus | 40 | microsome format | Scientific Literature | ||
9. | ALA4416177 | A | Clearance in rat liver microsomes at 0.5 uM measured up to 45 mins in presence of NADPH by HPLC-MS/MS analysis | Rattus norvegicus | 40 | microsome format | Scientific Literature | ||
10. | ALA4416178 | A | Clearance in human liver microsomes at 0.5 uM measured up to 45 mins in presence of NADPH by HPLC-MS/MS analysis | Homo sapiens | 40 | microsome format | Scientific Literature | ||
11. | ALA4416179 | F | Antiplasmodial activity against asexual form of Plasmodium falciparum NF54 assessed as reduction in male gametocytes activation preincubated for 48 hrs followed by gametocytes activation and measured after 24 hrs by fluorescence based automated inverted microscopic analysis | Plasmodium falciparum | 38 | organism-based format | Scientific Literature | ||
12. | ALA4416180 | F | Antiplasmodial activity against asexual form of Plasmodium falciparum NF54 assessed as reduction in female gametocytes activation preincubated for 48 hrs followed by gametocytes activation and measured after 24 hrs by fluorescence based automated inverted microscopic analysis | Plasmodium falciparum | 38 | organism-based format | Scientific Literature | ||
13. | ALA4416181 | A | Inhibition of human MAO-A | Homo sapiens | 1 | single protein format | Scientific Literature | ||
14. | ALA4416182 | A | Agonist activity at human beta2 adrenoceptor | Homo sapiens | 1 | single protein format | Scientific Literature | ||
15. | ALA4416183 | A | Antagonist activity at human beta2 adrenoceptor | Homo sapiens | 1 | single protein format | Scientific Literature | ||
16. | ALA4416184 | A | Agonist activity at human PXR | Homo sapiens | 1 | single protein format | Scientific Literature | ||
17. | ALA4416185 | A | Inhibition of human KCNQ1/KCNE1 | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
18. | ALA4416186 | A | Agonist activity at human aryl hydrocarbon receptor | Homo sapiens | 1 | single protein format | Scientific Literature | ||
19. | ALA4416187 | A | Inhibition of OATP1B1 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
20. | ALA4416188 | A | Inhibition of AChE (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature |