| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4433871 | B | Inhibition of recombinant human JMJD3 expressed in baculovirus infected Sf9 cells at 25 uM using biotinylated histone H3 peptide as substrate incubated for 15 mins followed by substrate addition and measured after 60 mins by AlphaScreen assay relative to control | Homo sapiens | 6 | ALA4433220 | cell-based format | Scientific Literature | |
| 2. | ALA4433872 | B | Inhibition of recombinant human JMJD3 expressed in baculovirus infected Sf9 cells using biotinylated histone H3 peptide as substrate incubated for 15 mins followed by substrate addition and measured after 60 mins by AlphaScreen assay | Homo sapiens | 1 | ALA4433220 | cell-based format | Scientific Literature | |
| 3. | ALA4433873 | B | Inhibition of UTX (unknown origin) using histone H3 peptide as substrate incubated for 30 mins followed by substrate addition by AlphaScreen assay | Homo sapiens | 1 | ALA4433220 | single protein format | Scientific Literature | |
| 4. | ALA4433874 | B | Selectivity ratio of IC50 for recombinant human JMJD3 to IC50 for UTX (unknown origin) | Homo sapiens | 1 | ALA4433220 | assay format | Scientific Literature | |
| 5. | ALA4433875 | A | Apparent permeability of the compound in pH 7.4 phosphate buffer solution at 0.5 mM incubated for 24 hrs under gentle shaking condition by HPLC-UV detector based PAMPA assay | 1 | ALA4433220 | assay format | Scientific Literature | ||
| 6. | ALA4433876 | F | Antiproliferative activity against human A375 cells incubated for 24 hrs by propidium iodide staining based flow cytometric analysis | Homo sapiens | 1 | ALA4433220 | cell-based format | Scientific Literature | |
| 7. | ALA4433877 | F | Cell cycle arrest in human A375 cells assessed as accumulation at G1 phase at 20 uM incubated for 24 hrs by propidium iodide staining-based flow cytometry (Rvb = 59.63%) | Homo sapiens | 1 | ALA4433220 | cell-based format | Scientific Literature | |
| 8. | ALA4433878 | F | Cell cycle arrest in human A375 cells assessed as accumulation at G1 phase at 40 uM incubated for 24 hrs by propidium iodide staining-based flow cytometry (Rvb = 59.63%) | Homo sapiens | 1 | ALA4433220 | cell-based format | Scientific Literature | |
| 9. | ALA4433879 | F | Cell cycle arrest in human A375 cells assessed as accumulation at G1 phase at 80 uM incubated for 24 hrs by propidium iodide staining-based flow cytometry (Rvb = 59.63%) | Homo sapiens | 1 | ALA4433220 | cell-based format | Scientific Literature | |
| 10. | ALA4433880 | F | Cell cycle arrest in human A375 cells assessed as accumulation at G1 phase at 100 uM incubated for 24 hrs by propidium iodide staining-based flow cytometry (Rvb = 59.63%) | Homo sapiens | 1 | ALA4433220 | cell-based format | Scientific Literature | |
| 11. | ALA4433881 | F | Cell cycle arrest in human A375 cells assessed as accumulation at S phase at 20 uM incubated for 24 hrs by propidium iodide staining-based flow cytometry (Rvb = 29.56%) | Homo sapiens | 1 | ALA4433220 | cell-based format | Scientific Literature | |
| 12. | ALA4433882 | F | Cell cycle arrest in human A375 cells assessed as accumulation at S phase at 40 uM incubated for 24 hrs by propidium iodide staining-based flow cytometry (Rvb = 29.56%) | Homo sapiens | 1 | ALA4433220 | cell-based format | Scientific Literature | |
| 13. | ALA4433883 | F | Cell cycle arrest in human A375 cells assessed as accumulation at S phase at 80 uM incubated for 24 hrs by propidium iodide staining-based flow cytometry (Rvb = 29.56%) | Homo sapiens | 1 | ALA4433220 | cell-based format | Scientific Literature | |
| 14. | ALA4433884 | F | Cell cycle arrest in human A375 cells assessed as accumulation at S phase at 100 uM incubated for 24 hrs by propidium iodide staining-based flow cytometry (Rvb = 29.56%) | Homo sapiens | 1 | ALA4433220 | cell-based format | Scientific Literature | |
| 15. | ALA4433885 | F | Cell cycle arrest in human A375 cells assessed as accumulation at G2/M phase at 20 uM incubated for 24 hrs by propidium iodide staining-based flow cytometry (Rvb = 10.81%) | Homo sapiens | 1 | ALA4433220 | cell-based format | Scientific Literature | |
| 16. | ALA4433886 | F | Cell cycle arrest in human A375 cells assessed as accumulation at G2/M phase at 40 uM incubated for 24 hrs by propidium iodide staining-based flow cytometry (Rvb = 10.81%) | Homo sapiens | 1 | ALA4433220 | cell-based format | Scientific Literature | |
| 17. | ALA4433887 | F | Cell cycle arrest in human A375 cells assessed as accumulation at G2/M phase at 80 uM incubated for 24 hrs by propidium iodide staining-based flow cytometry (Rvb = 10.81%) | Homo sapiens | 1 | ALA4433220 | cell-based format | Scientific Literature | |
| 18. | ALA4433888 | F | Cell cycle arrest in human A375 cells assessed as accumulation at G2/M phase at 100 uM incubated for 24 hrs by propidium iodide staining-based flow cytometry (Rvb = 10.81%) | Homo sapiens | 1 | ALA4433220 | cell-based format | Scientific Literature | |
| 19. | ALA4433889 | B | Inhibition of JMJD3 in human A375 cells assessed as reduction in decrease of the H3K27me2 level at 100 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4433220 | cell-based format | Scientific Literature |
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