| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4481328 | B | Inhibition of full length His-tagged human DDX3X expressed in Escherichia coli assessed as reduction in DDX3X helicase activity using FAM-labeled double stranded RNA as substrate after 40 mins by FRET assay relative to control | Homo sapiens | 21 | assay format | Scientific Literature | ||
| 2. | ALA4481332 | A | Inhibition of human DDX3X ATPase activity using DDX3 as substrate by ADP-Glo kinase assay | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 3. | ALA4481333 | A | Inhibition of human DDX1 helicase activity | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 4. | ALA4481334 | A | Cytotoxicity against human HuH7 cells after 3 days by MTT assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 5. | ALA4481337 | F | Antiviral activity against West Nile virus infected in human HuH7 cells incubated for 4 days by crystal violet staining based plaque reduction assay | West Nile virus | 10 | organism-based format | Scientific Literature | ||
| 6. | ALA4481340 | A | Apparent permeability of the compound by PAMPA | 7 | assay format | Scientific Literature | |||
| 7. | ALA4481341 | P | Aqueous solubility of the compound at 1 mg after 24 to 36 hrs by LC-MS/MS analysis | 7 | small-molecule physicochemical format | Scientific Literature | |||
| 8. | ALA4481342 | A | Metabolic stability in human liver microsomes at 50 uM after 60 mins in presence of NADPH-generating system by LC-UV-MS analysis | Homo sapiens | 7 | microsome format | Scientific Literature | ||
| 9. | ALA4616145 | F | Antiviral activity against Dengue virus serotype 2 New Guinea C infected at 50 TCID50 in human HuH7 cells assessed as inhibition of viral replication and 72 hrs later re-infected pre-seeded HuH7 cells with viral supernatant collected from previous infected and measured after 72 hrs by immunodetection assay | dengue virus type 2 | 21 | organism-based format | Scientific Literature | ||
| 10. | ALA4616146 | A | Cytotoxicity against human HuH7 cells assessed as reduction in cell viability by measuring ATP level measured after 72 hrs by CellTiter-Glo luminescent assay | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
| 11. | ALA4616148 | B | Inhibition of recombinant full length human His-tagged DDX3X expressed in Escherichia coli using dsRNA as substrate measured after 40 mins in presence of ATP by FRET assay | Homo sapiens | 24 | assay format | Scientific Literature |
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