# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4325024 | F | Antibacterial activity against Escherichia coli ATCC 25922 assessed as reduction in bacterial growth by broth microdilution method | Escherichia coli | 29 | organism-based format | Scientific Literature | ||
2. | ALA4325025 | F | Antibacterial activity against quinolone-resistant Klebsiella pneumoniae T6474 expressing broad spectrum beta-lactamase assessed as reduction in bacterial growth by broth microdilution method | Klebsiella pneumoniae | 29 | organism-based format | Scientific Literature | ||
3. | ALA4325026 | F | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as reduction in bacterial growth by broth microdilution method | Pseudomonas aeruginosa | 29 | organism-based format | Scientific Literature | ||
4. | ALA4325027 | B | Inhibition of recombinant Escherichia coli LpxC (1 to 300 residues) C125S mutant expressed in Escherichia coli BL21 AI assessed as change in melting temperature at 25 uM by Sypro orange dye based differential scanning fluorimetry | Escherichia coli | 21 | assay format | Scientific Literature | ||
5. | ALA4325028 | B | Inhibition of recombinant Pseudomonas aeruginosa LpxC (1 to 299 residues) C40S mutant expressed in Escherichia coli BL21 AI assessed as change in melting temperature at 25 uM by Sypro orange dye based differential scanning fluorimetry | Pseudomonas aeruginosa | 21 | assay format | Scientific Literature | ||
6. | ALA4325029 | P | n-Octanol/phopshate buffer partition coefficient, log D of the compound at pH 7.4 by LC/UV analysis | 29 | small-molecule physicochemical format | Scientific Literature | |||
7. | ALA4325031 | P | Solubility of compound at pH 4 incubated for 24 hrs by LC/UV analysis | 29 | small-molecule physicochemical format | Scientific Literature | |||
8. | ALA4325032 | P | Solubility of compound at pH 7 incubated for 24 hrs by LC/UV analysis | 29 | small-molecule physicochemical format | Scientific Literature | |||
9. | ALA4325033 | P | Solubility of compound at pH 9 incubated for 24 hrs by LC/UV analysis | 29 | small-molecule physicochemical format | Scientific Literature | |||
10. | ALA4325069 | B | Binding affinity to Acinetobacter baumannii LpxC at 25 uM by Sypro orange dye based differential scanning fluorimetry | Acinetobacter baumannii | 29 | assay format | Scientific Literature | ||
11. | ALA4325070 | F | Selectivity ratio of MIC for wild type Pseudomonas aeruginosa PAO1 to MIC for Pseudomonas aeruginosa PA2616 harboring mexAB-OprM isogenic efflux mutant | 27 | assay format | Scientific Literature |