# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4344213 | Binding | Antagonist activity at human CCR8 expressed in CHOK1 cells assessed as inhibition in CCL1-induced beta-arrestin 2 recruitment at 20 uM incubated for 30 mins followed by CCL1 addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay relative to control | Homo sapiens | 9 | ALA4342456 | cell-based format | Scientific Literature | |
2. | ALA4344214 | Binding | Antagonist activity at human Gs/Gi/o-coupled CHRM4 expressed in CHOK1 cells assessed as inhibition in acetylcholine-induced beta-arrestin 2 recruitment at 20 uM incubated for 30 mins followed by acetylcholine addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay relative to control | Homo sapiens | 9 | ALA4342456 | cell-based format | Scientific Literature | |
3. | ALA4344215 | Binding | Antagonist activity at human Gi/o-coupled CNR1 expressed in CHOK1 cells assessed as inhibition in CP55940-induced beta-arrestin 2 recruitment at 20 uM incubated for 30 mins followed by CP55940 addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay relative to control | Homo sapiens | 9 | ALA4342456 | cell-based format | Scientific Literature | |
4. | ALA4344216 | Binding | Antagonist activity at human Gi/o-coupled CNR2 expressed in CHOK1 cells assessed as inhibition in CP55940-induced beta-arrestin 2 recruitment at 20 uM incubated for 30 mins followed by CP55940 addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay relative to control | Homo sapiens | 9 | ALA4342456 | cell-based format | Scientific Literature | |
5. | ALA4344217 | Binding | Antagonist activity at human Gi/o-coupled CXCR4 expressed in mouse C2C12 cells assessed as inhibition in CXCL12-induced beta-arrestin 2 recruitment at 20 uM incubated for 30 mins followed by CXCL12 addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay relative to control | Homo sapiens | 9 | ALA4342456 | cell-based format | Scientific Literature | |
6. | ALA4344218 | Binding | Antagonist activity at human Gi/o-coupled DRD2L expressed in CHOK1 cells assessed as inhibition in dopamine-induced beta-arrestin 2 recruitment at 20 uM incubated for 30 mins followed by dopamine addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay relative to control | Homo sapiens | 9 | ALA4342456 | cell-based format | Scientific Literature | |
7. | ALA4344219 | Binding | Antagonist activity at human Gi/o-coupled FPR1 expressed in CHOK1 cells assessed as inhibition in WKYMVm-NH2-induced beta-arrestin 2 recruitment at 20 uM incubated for 30 mins followed by WKYMVm-NH2 addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay relative to control | Homo sapiens | 9 | ALA4342456 | cell-based format | Scientific Literature | |
8. | ALA4344220 | Binding | Antagonist activity at human GPR119 assessed as inhibition in oleoylethanolamide-induced beta-arrestin 2 recruitment at 20 uM incubated for 30 mins followed by oleoylethanolamide addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay relative to control | Homo sapiens | 9 | ALA4342456 | single protein format | Scientific Literature | |
9. | ALA4344221 | Binding | Antagonist activity at human Gq-coupled HCRTR2 expressed in CHOK1 cells assessed as inhibition in Orexin A-induced beta-arrestin 2 recruitment at 20 uM incubated for 30 mins followed by Orexin A addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay relative to control | Homo sapiens | 9 | ALA4342456 | cell-based format | Scientific Literature | |
10. | ALA4344222 | Binding | Antagonist activity at human Gq-coupled HRH1 expressed in CHOK1 cells assessed as inhibition in histamine-induced beta-arrestin 2 recruitment at 20 uM incubated for 30 mins followed by histamine addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay relative to control | Homo sapiens | 9 | ALA4342456 | cell-based format | Scientific Literature | |
11. | ALA4344223 | Binding | Antagonist activity at human Gq-coupled NPSR1b expressed in human U2OS cells assessed as inhibition in neuropeptide S-induced beta-arrestin 2 recruitment at 20 uM incubated for 30 mins followed by neuropeptide S addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay relative to control | Homo sapiens | 9 | ALA4342456 | cell-based format | Scientific Literature | |
12. | ALA4344224 | Binding | Antagonist activity at human Gq-coupled PRLHR expressed in CHOK1 cells assessed as inhibition in prolactin releasing peptide (1 to 31)-induced beta-arrestin 2 recruitment at 20 uM incubated for 30 mins followed by prolactin releasing peptide (1 to 31) addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay relative to control | Homo sapiens | 9 | ALA4342456 | cell-based format | Scientific Literature | |
13. | ALA4344225 | Binding | Antagonist activity at human Gs-coupled PTGIR assessed as inhibition in beraprost-induced beta-arrestin 2 recruitment at 20 uM incubated for 30 mins followed by beraprost- addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay relative to control | Homo sapiens | 9 | ALA4342456 | single protein format | Scientific Literature | |
14. | ALA4344232 | Binding | Antagonist activity at human Gq-coupled HCRTR2 expressed in CHOK1 cells assessed as inhibition in Orexin A-induced beta-arrestin 2 recruitment incubated for 30 mins followed by Orexin A addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay | Homo sapiens | 1 | ALA4342456 | cell-based format | Scientific Literature | |
15. | ALA4344233 | Binding | Antagonist activity at human Gs/Gi/o-coupled CHRM4 expressed in CHOK1 cells assessed as inhibition in acetylcholine-induced beta-arrestin 2 recruitment incubated for 30 mins followed by acetylcholine addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay | Homo sapiens | 1 | ALA4342456 | cell-based format | Scientific Literature | |
16. | ALA4344236 | Physicochemical | Stability of compound in pH 2.0 HCl aqueous solution assessed as parent compound remaining at 0.025 mmol measured after 24 hrs | 1 | ALA4342456 | small-molecule physicochemical format | Scientific Literature | ||
17. | ALA4344237 | Physicochemical | Stability of compound in pH 4.88 HCl aqueous solution assessed as parent compound remaining at 0.026 mmol measured after 24 hrs | 1 | ALA4342456 | small-molecule physicochemical format | Scientific Literature | ||
18. | ALA4344238 | Functional | Suppression of drug-induced cocaine-seeking behavior in C57BL/6J mouse assessed as reduction in morphine-conditioned place preference at 60 nmol, icv administered 20 mins prior to behavioral morphine addition measured twice weekly for 7 weeks | Mus musculus | 2 | ALA4342456 | organism-based format | Scientific Literature | |
19. | ALA4344239 | Functional | Suppression of drug-induced cocaine-seeking behavior in C57BL/6J mouse assessed as reduction in stress-induced reinstatement of morphine-CPP at 60 nmol, icv administered 20 mins prior to testing by forced swim test | Mus musculus | 2 | ALA4342456 | organism-based format | Scientific Literature | |
20. | ALA4344240 | Toxicity | Toxicity in C57BL/6J mouse assessed as induction of behavioral changes at 60 nmol, icv | Mus musculus | 1 | ALA4342456 | assay format | Scientific Literature |