| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4323785 | F | Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay | Homo sapiens | 35 | ALA4321836 | cell-based format | Scientific Literature | |
| 2. | ALA4323786 | A | Agonist activity at human luteinizing hormone receptor incubated for 60 mins by cell based TR-FRET assay | Homo sapiens | 3 | ALA4321836 | cell-based format | Scientific Literature | |
| 3. | ALA4323794 | F | Antagonist activity at human follicle stimulating hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition and measured after 120 mins by cell based TR-FRET assay | Homo sapiens | 5 | ALA4321836 | cell-based format | Scientific Literature | |
| 4. | ALA4323795 | F | Antagonist activity at luteinizing hormone receptor in mouse MLTC-1 cells assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition and measured after 30 mins by cell based TR-FRET assay | Mus musculus | 3 | ALA4321836 | cell-based format | Scientific Literature | |
| 5. | ALA4323796 | F | Antagonist activity at rat luteinizing hormone receptor expressed in rat ovary granulosa GLHR15 cell suspension assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition after 30 mins by cell based TR-FRET assay | Rattus norvegicus | 5 | ALA4321836 | cell-based format | Scientific Literature | |
| 6. | ALA4323797 | F | Antagonist activity at human thyroid stimulating hormone receptor expressed in rat HTC133 cells assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition and measured after 60 mins by cell based TR-FRET assay | Homo sapiens | 5 | ALA4321836 | cell-based format | Scientific Literature | |
| 7. | ALA4323798 | F | Antagonist activity at human RXFP1 assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by mutRelaxin agonist addition measured after 60 mins by cell based TR-FRET assay | Homo sapiens | 1 | ALA4321836 | cell-based format | Scientific Literature | |
| 8. | ALA4323799 | P | Lipophilicity, logD of the compound at pH 7.5 by reversed-phase HPLC | 32 | ALA4321836 | small-molecule physicochemical format | Scientific Literature | ||
| 9. | ALA4323800 | A | Clearance in human liver microsomes at 1 uM measured after 2 to 60 mins in presence of glucose-6-phosphate by LC-MS/MS analysis | Homo sapiens | 30 | ALA4321836 | microsome format | Scientific Literature | |
| 10. | ALA4323801 | A | Maximum oral bioavailability in human liver microsomes based well stirred liver model at 1 uM measured after 2 to 60 mins in presence of glucose-6-phosphate by LC-MS/MS analysis | Homo sapiens | 30 | ALA4321836 | organism-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!