# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4345738 | F | Cytotoxicity against human SUM159 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
2. | ALA4345739 | F | Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
3. | ALA4345740 | B | Activation of LATS1 in triple-negative human SUM159 cells transfected with YAP/TAZ-TEAD reporter plasmid containing 8xGTIIC binding site and cotransfected with pCMV-Luc assessed as suppression of YAP/TAZ luciferase activity measured after 12 hrs by dual luciferase reporter assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
4. | ALA4345741 | B | Activation of LATS1 in triple-negative human SUM159 cells assessed as induction of YAP degradation by measuring suppression of YAP protein expression at 0.25 to 1 uM measured after 12 hrs by Western blot analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
5. | ALA4345742 | B | Activation of LATS1 in triple-negative human SUM159 cells assessed as effect on YAP mRNA level at 0.25 to 1 uM measured after 12 hrs by Trizol reagent based RT-PCR analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
6. | ALA4345743 | B | Activation of LATS1 in triple-negative human SUM159 cells assessed as induction of YAP degradation by measuring suppression of YAP protein expression at 0.25 to 1 uM measured after 12 hrs in presence of 10 uM proteosomal inhibitor, MG132 by Western blot analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
7. | ALA4345744 | B | Activation of LATS1 in human MDA-MB-231 cells assessed as induction of YAP degradation by measuring suppression of YAP protein expression at 0.5 uM pretreated with compound for 24 hrs followed by incubation with protein synthesis inhibitor, CHX up to 48 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
8. | ALA4345745 | F | Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
9. | ALA4345746 | F | Cytotoxicity against human PC3 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
10. | ALA4345747 | F | Cytotoxicity against human PC9 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
11. | ALA4345748 | F | Cytotoxicity against human SUM159 cells assessed as reduction in cell viability at 0.2 to 1.2 uM by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
12. | ALA4345749 | F | Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability at 0.2 to 1.2 uM by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
13. | ALA4345750 | F | Cytotoxicity against human PC3 cells assessed as reduction in cell viability at 0.2 to 1.2 uM by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
14. | ALA4345751 | F | Cytotoxicity against human PC9 cells assessed as reduction in cell viability at 0.2 to 1.2 uM by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
15. | ALA4345752 | F | Cytotoxicity against human MDA-MB-231 cells ectopically overexpressed with wild type FLAG-tagged YAP assessed as reduction in cell viability at 0.2 to 1.2 uM measured after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
16. | ALA4345753 | B | Activation of LATS1 in human SUM159 cells assessed as increase in YAP phosphorylation at Ser397 at 0.25 to 1.5 uM measured after 12 to 24 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
17. | ALA4345754 | B | Activation of LATS1 in human MDA-MB-321 cells assessed as increase in YAP phosphorylation at Ser397 at 0.25 to 1.5 uM measured after 12 to 24 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
18. | ALA4345755 | B | Activation of LATS1 in human PC3 cells assessed as increase in YAP phosphorylation at Ser397 at 0.25 to 1.5 uM measured after 12 to 24 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
19. | ALA4345756 | B | Activation of LATS1 in human PC9 cells assessed as increase in YAP phosphorylation at Ser397 at 0.25 to 1.5 uM measured after 12 to 24 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
20. | ALA4345757 | B | Activation of LATS1 in human SUM159 cells assessed as increase in YAP phosphorylation at Ser397 at 0.25 to 1.5 uM measured after 24 to 48 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature |