# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4365247 | B | Antagonist activity at rat alpha3beta2 nACHR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potential by two electrode voltage-clamp assay | Rattus norvegicus | 38 | cell-based format | Scientific Literature | ||
2. | ALA4365248 | A | Antagonist activity at rat alpha6alpha3beta2beta3 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potential by two electrode voltage-clamp assay | Rattus norvegicus | 38 | cell-based format | Scientific Literature | ||
3. | ALA4365249 | B | Selectivity ratio of IC50 for rat alpha6/alpha3beta2beta3 nAChR expressed in Xenopus laevis oocytes to IC50 for rat alpha3beta2 nACHR expressed in Xenopus laevis oocytes | Rattus norvegicus | 41 | cell-based format | Scientific Literature | ||
4. | ALA4365251 | B | Selectivity ratio, ratio of IC50 for rat alpha3beta4 nACHR expressed in Xenopus laevis oocytes to IC50 for rat alpha3beta2 nACHR expressed in Xenopus laevis oocytes | Rattus norvegicus | 5 | cell-based format | Scientific Literature | ||
5. | ALA4365271 | B | Selectivity ratio of IC50 for rat alpha6beta4 nAChR expressed in Xenopus laevis oocytes to IC50 for rat alpha3beta2 nACHR expressed in Xenopus laevis oocytes | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
6. | ALA4365272 | B | Selectivity ratio of IC50 for rat alpha6beta2 nAChR expressed in Xenopus laevis oocytes to IC50 for rat alpha3beta2 nACHR expressed in Xenopus laevis oocytes | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
7. | ALA4705577 | B | Antagonist activity at rat alpha3beta2 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potential incubated for 5 mins by voltage-clamp assay | Rattus norvegicus | 17 | cell-based format | Scientific Literature | ||
8. | ALA4705578 | B | Antagonist activity at rat alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potential incubated for 5 mins by voltage-clamp assay | Rattus norvegicus | 17 | cell-based format | Scientific Literature | ||
9. | ALA4705579 | B | Selectivity index, ratio of IC50 for rat alpha3beta4 nAChR expressed in Xenopus laevis oocytes to IC50 for rat alpha3beta2 nAChR expressed in Xenopus laevis oocytes | Rattus norvegicus | 17 | cell-based format | Scientific Literature | ||
10. | ALA4705580 | B | Displacement of [125I]-alpha-bungarotoxin from Aplysia californica C-terminal His6-tagged N-terminal gp67 signal peptide-tagged acetylcholine receptor binding protein expressed in Hi5 insect cells preincubated for 3 hrs followed by [125I]-alpha-bungarotoxin measured after 5 mins by radioligand binding assay | Aplysia californica | 12 | cell-based format | Scientific Literature | ||
11. | ALA4705582 | B | Antagonist activity at wild type rat alpha3beta2 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at 1 uM at -70 mV holding potential measured after 5 mins by voltage-clamp assay relative to control | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
12. | ALA4705583 | B | Antagonist activity at rat alpha3beta2 nAChR F106V mutant expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at 1 uM at -70 mV holding potential measured after 5 mins by voltage-clamp assay relative to control | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
13. | ALA4705584 | B | Antagonist activity at rat alpha3beta2 nAChR S108T mutant expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at 1 uM at -70 mV holding potential measured after 5 mins by voltage-clamp assay relative to control | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
14. | ALA4705585 | B | Antagonist activity at rat wild-type alpha3beta2 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at 10 nM at -70 mV holding potential measured after 5 mins by voltage-clamp assay relative to control | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
15. | ALA4705586 | B | Antagonist activity at rat alpha3beta2 nAChR S113R mutant expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at 10 nM at -70 mV holding potential measured after 5 mins by voltage-clamp assay relative to control | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
16. | ALA4705587 | B | Antagonist activity at rat alpha3beta2 nAChR F106V mutant expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potential measured after 5 mins by voltage-clamp assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
17. | ALA4705588 | B | Antagonist activity at rat alpha3beta2 nAChR S108T mutant expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potential measured after 5 mins by voltage-clamp assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
18. | ALA4705589 | B | Antagonist activity at rat alpha3beta2 nAChR A110V mutant expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potential measured after 5 mins by voltage-clamp assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
19. | ALA4705590 | B | Antagonist activity at rat alpha3beta2 nAChR S113R mutant expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potential measured after 5 mins by voltage-clamp assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
20. | ALA4705591 | B | Antagonist activity at rat alpha3beta2 nAChR Y114S mutant expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potential measured after 5 mins by voltage-clamp assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature |