| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4322494 | B | Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal GST-fused mTOR (1360 to 2549 residues) expressed in baculovirus expression system by TR-FRET assay | Homo sapiens | 23 | assay format | Scientific Literature | ||
| 2. | ALA4322495 | B | Inhibition of mTORC2 in human A2058 cells assessed as reduction in PKB phosphorylation at S473 residues incubated for 1 hr by Western blot analysis | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
| 3. | ALA4322496 | B | Inhibition of mTORC1 in human A2058 cells assessed as reduction in ribosomal protein S6 phosphorylation at Ser235/236 residues incubated for 1 hr by Western blot analysis | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
| 4. | ALA4322497 | B | Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human full-length N-terminal His6-tagged p110alpha/p85alpha expressed in baculovirus expression system by TR-FRET assay | Homo sapiens | 29 | assay format | Scientific Literature | ||
| 5. | ALA4322498 | B | Selectivity ratio of Ki for inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human full-length N-terminal His6-tagged p110alpha/p85alpha expressed in baculovirus expression system to Ki for inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal GST-fused mTOR (1360 to 2549 residues) expressed in baculovirus expression system | Homo sapiens | 23 | assay format | Scientific Literature | ||
| 6. | ALA4322499 | A | Substrate activity at recombinant human CYP1A1 expressed in baculovirus infected insect cells assessed as parent compound remaining at 1 uM incubated for 60 mins in presence of NADP+-regenerating system by LC-MS analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 7. | ALA4322500 | A | Substrate activity at recombinant human CYP1A2 expressed in baculovirus infected insect cells assessed as parent compound remaining at 1 uM incubated for 60 mins in presence of NADP+-regenerating system by LC-MS analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 8. | ALA4322501 | A | Substrate activity at recombinant human CYP1A1 expressed in baculovirus infected insect cells assessed as parent compound remaining at 1 uM incubated for 60 mins in absence of NADP+-regenerating system by LC-MS analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 9. | ALA4322502 | A | Substrate activity at recombinant human CYP1A2 expressed in baculovirus infected insect cells assessed as parent compound remaining at 1 uM incubated for 60 mins in absence of NADP+-regenerating system by LC-MS analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 10. | ALA4322503 | B | Binding affinity to wild-type human partial length mTOR (L1382 to W2549 residues) expressed in mammalian expression system by kinome scan assay | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 11. | ALA4322504 | B | Binding affinity to human wild-type partial length PI3Kalpha (R108 to N1068 residues) expressed in mammalian expression system by kinome scan assay | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 12. | ALA4322505 | B | Binding affinity to human wild-type partial length PI3Kbeta (P118 to S1070 residues) expressed in mammalian expression system by kinome scan assay | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 13. | ALA4322506 | B | Binding affinity to human wild-type partial length PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system by kinome scan assay | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 14. | ALA4322507 | B | Binding affinity to human wild-type partial length PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system by kinome scan assay | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 15. | ALA4322508 | B | Binding affinity to wild-type human full-length PI4Kbeta (M1 to M828 residues) expressed in mammalian expression system by kinome scan assay | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 16. | ALA4322509 | B | Binding affinity to human wild-type partial length VPS34 (S282 to H879 residues) expressed in mammalian expression system by kinome scan assay | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 17. | ALA4322510 | B | Selectivity ratio of Kd for binding affinity to human wild-type partial length PI3Kalpha (R108 to N1068 residues) expressed in mammalian expression system to Kd for binding affinity to wild-type human partial length mTOR (L1382 to W2549 residues) expressed in mammalian expression system | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 18. | ALA4732437 | A | Stability of compound assessed as recombinant human CYP1A1 expressed in baculovirus infected insect cells mediated compound metabolism by measuring parent compound remaining at 1 uM preincubated with NADP+ regenerating system for 10 mins followed by enzyme addition and measured after 60 mins by LC-MS analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 19. | ALA4732443 | A | Stability of compound assessed as recombinant human CYP1A2 expressed in baculovirus infected insect cells mediated compound metabolism by measuring parent compound remaining at 1 uM preincubated with NADP+ regenerating system for 10 mins followed by enzyme addition and measured after 60 mins by LC-MS analysis | Homo sapiens | 4 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!