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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA4625372 Functional Antitumor activity against human H22 cells xenografted in BALB/c mouse assessed as reduction in tumor growth by measuring T/C ratio at 60 mg/kg, po bid via gavage measured after 20 days relative to control Mus musculus 2 ALA4622946 organism-based format Scientific Literature 2. ALA4625373 Functional Antitumor activity against human H22 cells xenografted in BALB/c mouse assessed as reduction in tumor growth by measuring T/C ratio at 120 mg/kg, po bid via gavage measured after 20 days relative to control Mus musculus 1 ALA4622946 organism-based format Scientific Literature 3. ALA4625375 ADME AUC in BALB/c mouse xenografted with human H22 cells at 60 mg/kg, po bid via gavage measured at day 1 Mus musculus 2 ALA4622946 organism-based format Scientific Literature 4. ALA4625376 ADME AUC in BALB/c mouse xenografted with human H22 cells at 120 mg/kg, po bid via gavage measured at day 1 Mus musculus 1 ALA4622946 organism-based format Scientific Literature 5. ALA4625378 ADME AUC in BALB/c mouse xenografted with human H22 cells at 120 mg/kg, po bid via gavage measured at day 19 Mus musculus 1 ALA4622946 organism-based format Scientific Literature 6. ALA4625379 ADME AUC in BALB/c mouse xenografted with human H22 cells at 60 mg/kg, po bid via gavage measured at day 19 Mus musculus 2 ALA4622946 organism-based format Scientific Literature 7. ALA4625385 Toxicity Toxicity in BALB/c mouse xenografted with human H22 cells assessed as effect on body weight at 60 to 120 mg/kg, po bid via gavage Mus musculus 1 ALA4622946 organism-based format Scientific Literature 8. ALA4769705 Binding Inhibition of ALK5 (unknown origin) measured after 120 mins of incubation by ADP-Glo kinase assay Homo sapiens 28 ALA4765311 single protein format Scientific Literature 9. ALA4769707 Binding Inhibition of TGF-beta type 1 receptor in mouse NIH3T3 cells expressing Luc-Smad 2/3 measured after 24 hrs incubation by cell based Bright-Glo Luciferase assay Mus musculus 28 ALA4765311 cell-based format Scientific Literature 10. ALA4769708 ADME Half life in BALB/c mouse at 1 mg/kg, iv measured upto 24 hr by LC-MS/MS analysis Mus musculus 8 ALA4765311 organism-based format Scientific Literature 11. ALA4769709 ADME Clearance in BALB/c mouse at 1 mg/kg, iv measured upto 24 hr by LC-MS/MS analysis Mus musculus 8 ALA4765311 organism-based format Scientific Literature 12. ALA4769710 ADME Volume of distribution at steady state in BALB/c mouse at 1 mg/kg, iv measured upto 24 hr by LC-MS/MS analysis Mus musculus 8 ALA4765311 organism-based format Scientific Literature 13. ALA4769711 ADME AUC (0 to 24 hrs) in BALB/c mouse at 1 mg/kg, iv measured upto 24 hr by LC-MS/MS analysis Mus musculus 8 ALA4765311 organism-based format Scientific Literature 14. ALA4769712 ADME Half life in BALB/c mouse at 10 mg/kg, po measured upto 24 hr by LC-MS/MS analysis Mus musculus 8 ALA4765311 organism-based format Scientific Literature 15. ALA4769713 ADME Cmax in BALB/c mouse at 10 mg/kg, po measured upto 24 hr by LC-MS/MS analysis Mus musculus 8 ALA4765311 organism-based format Scientific Literature 16. ALA4769714 ADME AUC (0 to 24 hrs) in BALB/c mouse at 10 mg/kg, po measured upto 24 hr by LC-MS/MS analysis Mus musculus 8 ALA4765311 organism-based format Scientific Literature 17. ALA4769715 ADME Oral bioavailability in BALB/c mouse at 10 mg/kg measured upto 24 hrs by LC-MS/MS analysis Mus musculus 8 ALA4765311 organism-based format Scientific Literature 18. ALA5133846 ADME Half life in BALB/c mouse at 1 mg/kg, iv Mus musculus 6 ALA5131446 organism-based format Scientific Literature 19. ALA5133847 ADME Clearance in BALB/c mouse at 1 mg/kg, iv Mus musculus 6 ALA5131446 organism-based format Scientific Literature 20. ALA5133848 ADME Volume of distribution at steady state in BALB/c mouse at 1 mg/kg, iv Mus musculus 6 ALA5131446 organism-based format Scientific Literature