# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5168873 | Functional | Antiproliferative activity against human PC-3M cells expressing PTB/GFP fusion protein assessed as disruption of RNA synthesis marker RP-194 at 1 uM and measured after 1 hr by DAPI staining based immunofluorescence microscopy | Homo sapiens | 1 | ALA5154945 | cell-based format | Scientific Literature | |
2. | ALA5168874 | ADME | Cmax in male C57BL/6 mouse at 50 mg/kg, ip at 30 min by LC-MS/MS analysis | Mus musculus | 2 | ALA5154945 | organism-based format | Scientific Literature | |
3. | ALA5168875 | Functional | Anticancer activity in human PC-3M cells expressing PTB/GFP fusion protein assessed as perinucleolar compartment disassembly and measured after 24 hrs by Hoechst 33342 staining based microscopic method | Homo sapiens | 81 | ALA5154945 | cell-based format | Scientific Literature | |
4. | ALA5168876 | Toxicity | Cytotoxicity against human PC-3M cells expressing PTB/GFP fusion protein assessed as reduction in ATP level and measured after 24 to 48 hrs by ATPlite luminescence assay | Homo sapiens | 4 | ALA5154945 | cell-based format | Scientific Literature | |
5. | ALA5168877 | ADME | Therapeutic window, ratio of IC50 for cytotoxicity against human PC-3M cells expressing PTB/GFP fusion protein assessed as reduction in ATP level to IC50 for anticancer activity in human PC-3M cells expressing PTB/GFP fusion protein assessed as reduction of perinucleolar compartment | 4 | ALA5154945 | cell-based format | Scientific Literature | ||
6. | ALA5168878 | ADME | Permeability of the compound at pH 7.4 incubated for 30 mins by UV plate reader based PAMPA assay | 79 | ALA5154945 | assay format | Scientific Literature | ||
7. | ALA5168879 | ADME | Microsomal stability in CD1 mouse liver microsomes assessed as half life measured upto 60 mins in presence of NADPH by LC-MS analysis | Mus musculus | 79 | ALA5154945 | microsome format | Scientific Literature | |
8. | ALA5168880 | Functional | Antiproliferative activity against human PC-3M cells expressing PTB/GFP fusion protein assessed as cell growth inhibition at < 100 nM and measured every four hrs for 130 hrs by IncuCyte zoom live cell analysis | Homo sapiens | 2 | ALA5154945 | cell-based format | Scientific Literature | |
9. | ALA5168881 | Functional | Antiproliferative activity against human PC-3M cells expressing PTB/GFP fusion protein assessed as cell growth inhibition at 0.1 to 10 uM and measured every four hrs for 130 hrs by IncuCyte zoom live cell analysis | Homo sapiens | 1 | ALA5154945 | cell-based format | Scientific Literature | |
10. | ALA5168882 | Toxicity | Cytotoxicity against human PC-3M cells expressing PTB/GFP fusion protein assessed as reduction in ATP level at 20 uM and measured after 24 to 48 hrs by ATPlite luminescence assay | Homo sapiens | 2 | ALA5154945 | cell-based format | Scientific Literature | |
11. | ALA5168884 | Functional | Antiproliferative activity against human PC-3M cells expressing PTB/GFP fusion protein assessed as inhibition of nucleolar volume measured after 24 hrs by Nucleolar-id Green Detection based confocal microscopic analysis | Homo sapiens | 3 | ALA5154945 | cell-based format | Scientific Literature | |
12. | ALA5168885 | Functional | Antiproliferative activity against human PC-3M cells expressing PTB/GFP fusion protein assessed as reduction of nucleolar volume at 1 to 30 uM measured after 24 hrs by Nucleolar-id Green Detection based confocal microscopic analysis | Homo sapiens | 2 | ALA5154945 | cell-based format | Scientific Literature | |
13. | ALA5168886 | Functional | Antiproliferative activity against human PC-3M cells expressing PTB/GFP fusion protein assessed as disruption of RNA synthesis marker NOPP140 at 1 uM measured after 1 hr by DAPI staining based immunofluorescence microscopy | Homo sapiens | 1 | ALA5154945 | cell-based format | Scientific Literature | |
14. | ALA5168887 | Physicochemical | Kinetic solubility of compound | 5 | ALA5154945 | small-molecule physicochemical format | Scientific Literature | ||
15. | ALA5168888 | ADME | Cmax in female BALB/c mouse at 5 mg/kg, ip at 30 min by LC-MS/MS analysis | Mus musculus | 1 | ALA5154945 | organism-based format | Scientific Literature | |
16. | ALA5168889 | ADME | Cmax in female BALB/c mouse at 25 mg/kg, ip at 30 min by L-MS/MS analysis | Mus musculus | 1 | ALA5154945 | organism-based format | Scientific Literature | |
17. | ALA5168890 | ADME | Tmax in male C57BL/6 mouse at 50 mg/kg, ip and measured upto 48 hrs by LC-MS/MS analysis | Mus musculus | 2 | ALA5154945 | organism-based format | Scientific Literature | |
18. | ALA5168891 | ADME | Tmax in female BALB/c mouse at 5 mg/kg, ip and measured upto 48 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA5154945 | organism-based format | Scientific Literature | |
19. | ALA5168892 | ADME | Tmax in female BALB/c mouse at 25 mg/kg, ip and measured upto 48 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA5154945 | organism-based format | Scientific Literature | |
20. | ALA5168893 | ADME | Clast in male C57BL/6 mouse at 50 mg/kg, ip at 48 hrs by LC-MS/MS analysis | Mus musculus | 2 | ALA5154945 | organism-based format | Scientific Literature |